Topotecan

Introduction: Topotecan

Description of Topotecan

Topotecan: A semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Topotecan inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death. Because ongoing DNA synthesis is necessary for topotecan to exert its cytotoxic effects, it is classified as an S-phase-specific agent. (NCI04)
Source: Diseases Database

Topotecan: antineoplastic drug which acts as a DNA topoisomerase inhibitor.
Source: CRISP

Topotecan: An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA TOPOISOMERASES, TYPE I.
Source: MeSH 2007

Topotecan: Related Topics

These medical condition or symptom topics may be relevant to medical information for Topotecan:

• Semisynthetic
• Derivative
• Camptothecin
• Cytotoxic
• Quinoline
• Alkaloid
• Asian
• Camptotheca

Terms associated with Topotecan:

Broader terms for Topotecan

• camptothecin

Source - CRISP

The term Topotecan can be used for:

• Hyamptin

Source: CRISP

Other terms that may be related to Topotecan:

• radiosensitizer

Source: CRISP

External links related to: Topotecan

• Hycamtin Online, Description, Chemistry, Ingredients - Topotecan - RxList Monographs
• Newly Approved Drug Therapies (121): Hycamtin (topotecan hydrochloride), SmithKline Beecham
• Ovarian cancer (advanced) - paclitaxel, pegylated liposomal doxorubicin hydrochloride and topotecan (review) (No. 91)
• Full guidance on topotecan for ovarian cancer - text (html) version
• CancerSourceMD.Com Drug Guide

Source: Diseases Database

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Urethral Neoplasms

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