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Dictionary » Urokinase


Introduction: Urokinase

Description of Urokinase

Urokinase: Encoded by human PLAU Gene (Peptidase S1 Family), 431-aa 48.5-kD single-chain Urokinase precursor contains a kringle and an EGF-like domain. A potent activator of plasminogen to plasmin conversion by Arg-Val cleavage, the two-chain serine protease is composed of disulfide-linked A (18,000 D) and B (33,000 D) chains that arise from precursor Lys(158)-Ile(159) cleavage by plasmin. Urokinase occurs in high and low mass forms, each consisting of A and B chains. The high mass form contains a long A chain; cleavage after residue 155 in the low mass form yields a short A1 chain. Urokinase is immunologically unrelated to TPA. (from LocusLink, Swiss-Prot, OMIM, and NCI)
Source: Diseases Database

Urokinase: EC
Source: CRISP

Urokinase: Related Topics

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Source: Diseases Database

Broader terms for Urokinase

Source - CRISP

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Source: CRISP

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