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Data analysis from two trials involving 22,579 women aged 50-79 with hysterectomies has found that gall bladder disease or gallbladder surgery was more prevalent in women who had estrogen therapy. The risk of gallbladder disease or surgery was increased by 67% with conjugated equine estrogens and 59% with estrogen and progestin. The risk of gallbladder inflammation (cholecystitis) increased by 80% with conjugated equine estrogens and 54% with estrogen and progestin. The risk of cholelithiasis increased by 86% with conjugated equine estrogen and 68% with estrogen and progestin. Thus it was found that conjugated equine estrogen led to an extra 31 cases of gallbladder disease each year per 10,000 women and estrogen and progestrin led to an extra 20 per 10,000 women.
Source: summary of medical news story as reported by Eurekalert
About: Use of estrogen by women with hysterectomies may increase the risk of gallbladder disease
Date: 18 January 2005
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