Paget's disease of bone is a chronic bone disease. For the similarly named disease of the breast, see Paget's disease of breast. ...more »
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Paget's disease of bone is a chronic (long-term) disorder that typically results in enlarged and deformed bones. Excessive bone breakdown and formation cause thick and fragile bone. As a result, bone pain, arthritis, noticeable deformities, and fractures can occur. The disease can affect any bone of the body, but is often found in the spine. The blood supply that feeds healthy nerve tissue may be diverted to the area of involved bone. Also, structural deformities of the involved vertebrae can cause narrowing of the spinal canal, producing a variety of neurological symptoms. (Source: excerpt from Questions and Answers About Spinal Stenosis: NIAMS)
Paget's Disease is a disease of bone that initially results in the excessive resorption of bone (by osteoclasts) followed by the replacement of normal bone marrow with vascular and fibrous tissue. (On-line Medical Dictionary) - (Source - Diseases Database)
A disease of bone occurring in the middle aged and elderly; excessive bone destruction sometimes leading to bone pain and fractures and skeletal deformities - (Source - WordNet 2.1)
Paget's disease of bone is listed as a "rare disease" by the Office of
Rare Diseases (ORD) of the National Institutes of Health
(NIH). This means that Paget's disease of bone, or a subtype of Paget's disease of bone,
affects less than 200,000 people in the US population.
Source - National Institutes of Health (NIH)
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