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Treatments for Parkinson disease 3, autosomal dominant Lewy body (PARK3)

Treatment List for Parkinson disease 3, autosomal dominant Lewy body (PARK3)

The list of treatments mentioned in various sources for Parkinson disease 3, autosomal dominant Lewy body (PARK3) includes the following list. Always seek professional medical advice about any treatment or change in treatment plans.

  • There is no cure for the disease but various therapies may improve quality of life and comfort: support group, adequate nutrition, exercise, physiotherapy, rehabilitation and regular health checks. Medications that may help some patients include Levodopa, COMT inhibitors (e.g. Tolcapone, Entacapone), dopamine agonists and MAO-B inhibitors, anticholinergic drugs - the benefits of these medications often have to be weighed up against the side effects. Surgical procedures such as deep brain stimulation and pallidotomy may also help some patients. Complementary therapies can also improve symptoms and the more notable ones include: supplements of L-tyrosine, ferrous iron, pyridoxine, NADH, THFA, coenzyme Q10 and plant-derived mucuna may provide varying degrees of benefit.
  • Treatment is aimed at providing symptomatic relief, and does not slow the progression of the disease. Drug therapy is the main treatment available and includes:
    • Levadopa - first line for most people, especially the elderly and those with cognitive impairment
    • Dopamine antagonists - Bromocriptine, Cabergoline, Pergolide, Apomorphine
    • Selegiline
    • Amantadine
    • Entacapone
    • Anticholinergic drugs - behexol, benztropine, biperiden, orphenadrine
  • All of these medications have side effects, some of them significant, so medications need to be titrated carefully and benefits weighed up against adverse effects
  • Autonomic dysfunction - orthostatic hypotension, constipation, neurogenic bladder disturbances and sexual dysfunction - need to be sought and treated as necessary. Depression, dementia and pain may also need to be addressed
  • Surgical procedures such as deep brain stimulation and pallidotomy may also help some patients
  • Complementary therapies suggested to improve symptoms include: supplements of L-tyrosine, ferrous iron, pyridoxine, NADH, THFA, coenzyme Q10 and plant-derived mucuna which may provide varying degrees of benefit
  • Physiotherapy and occupational therapy may benefit some patients

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