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Treatments for Parkinson disease 6, autosomal recessive early-onset (PARK6)

Treatment List for Parkinson disease 6, autosomal recessive early-onset (PARK6)

The list of treatments mentioned in various sources for Parkinson disease 6, autosomal recessive early-onset (PARK6) includes the following list. Always seek professional medical advice about any treatment or change in treatment plans.

  • There is no cure for the disease but various therapies may improve quality of life and comfort: support group, adequate nutrition, exercise, physiotherapy, rehabilitation and regular health checks. Medications that may help some patients include Levodopa, COMT inhibitors (e.g. Tolcapone, Entacapone), dopamine agonists and MAO-B inhibitors, anticholinergic drugs - the benefits of these medications often have to be weighed up against the side effects. Surgical procedures such as deep brain stimulation and pallidotomy may also help some patients. Complementary therapies can also improve symptoms and the more notable ones include: supplements of L-tyrosine, ferrous iron, pyridoxine, NADH, THFA, coenzyme Q10 and plant-derived mucuna may provide varying degrees of benefit.
  • Treatment similar to Parkinson's disease in older patients, but younger patients seem to be at higher risk of complications of long term levadopa treatment
  • Treatment should be aimed at controlling the most troubling symptoms and include:
    • Levadopa - use of levadopa may be delayed as long as possible due to risk of complications with long term treatment in younger people
    • Dopamine antagonists - Bromocriptine, Cabergoline, Pergolide, Apomorphine
    • Selegiline
    • Amantadine
    • Entacapone
    • Anticholinergic drugs - behexol, benztropine, biperiden, orphenadrine
  • Autonomic dysfunction - orthostatic hypotension, constipation, neurogenic bladder disturbances and sexual dysfunction - need to be sought and treated as necessary. Depression, dementia and pain may also need to be addressed
  • Stereotaxic neurosurgical treatment may benefit younger patients with motor fluctuations or symptoms resistant to medication
  • Complementary therapies suggested to improve symptoms include: supplements of L-tyrosine, ferrous iron, pyridoxine, NADH, THFA, coenzyme Q10 and plant-derived mucuna, which may provide varying degrees of benefit
  • A team approach including physiotherapy and occupational therapy can benefit patients

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