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Pelizaeus-Merzbacher Disease

Pelizaeus-Merzbacher Disease: Introduction

Pelizaeus-Merzbacher Disease: Pelizaeus-Merzbacher disease is a rare, progressive, degenerative central nervous system disorder in which coordination, motor ... more about Pelizaeus-Merzbacher Disease.

Pelizaeus-Merzbacher Disease: Rare brain myelin disorder. More detailed information about the symptoms, causes, and treatments of Pelizaeus-Merzbacher Disease is available below.

Symptoms of Pelizaeus-Merzbacher Disease

Home Diagnostic Testing

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Wrongly Diagnosed with Pelizaeus-Merzbacher Disease?

Pelizaeus-Merzbacher Disease: Related Patient Stories

Pelizaeus-Merzbacher Disease: Deaths

Read more about Deaths and Pelizaeus-Merzbacher Disease.

Types of Pelizaeus-Merzbacher Disease

  • Classic Pelizaeus-Merzbacher Disease
  • Adult Pelizaeus-Merzbacher Disease
  • more types...»

Pelizaeus-Merzbacher Disease: Complications

Read more about complications of Pelizaeus-Merzbacher Disease.

Causes of Pelizaeus-Merzbacher Disease

Read more about causes of Pelizaeus-Merzbacher Disease.

Disease Topics Related To Pelizaeus-Merzbacher Disease

Research the causes of these diseases that are similar to, or related to, Pelizaeus-Merzbacher Disease:

Pelizaeus-Merzbacher Disease: Undiagnosed Conditions

Commonly undiagnosed diseases in related medical categories:

Misdiagnosis and Pelizaeus-Merzbacher Disease

Undiagnosed stroke leads to misdiagnosed aphasia: BBC News UK reported on a man who had been institutionalized and treated for mental illness because he suffered from sudden inability to speak. This was initially...read more »

Dementia may be a drug interaction: A common scenario in aged care is for a patient to show mental decline to dementia. Whereas this can, of course, occur due to various medical conditions, such as a stroke or Alzheimer's...read more »

Leg cramps at night a classic sign: The symptom of having leg muscle cramps, particularly at night, is a classic sign of undiagnosed diabetes. However, there are also various other causes. See causes of leg...read more »

Mild traumatic brain injury often remains undiagnosed: Although the symptoms of severe brain injury are hard to miss, it is less clear for milder injuries, or even those causing a mild concussion diagnosis. The condition goes by the...read more »

MTBI misdiagnosed as balance problem: When a person has symptoms such as vertigo or dizziness, a diagnosis of brain injury may go overlooked. This is...read more »

Brain pressure condition often misdiagnosed as dementia: A condition that results from an excessive pressure of CSF within the brain is often misdiagnosed. It may be...read more »

Post-concussive brain injury often misdiagnosed: A study found that soldiers who had suffered a concussive injury in battle often were misdiagnosed on their return....read more »

Children with migraine often misdiagnosed: A migraine often fails to be correctly diagnosed in pediatric patients. These patients are not the typical migraine sufferers, but...read more »

Vitamin B12 deficiency under-diagnosed: The condition of Vitamin B12 deficiency is a possible misdiagnosis of various conditions, such as multiple sclerosis (see symptoms of multiple sclerosis)....read more »

Pelizaeus-Merzbacher Disease: Research Doctors & Specialists

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Pelizaeus-Merzbacher Disease: Rare Types

Rare types of diseases and disorders in related medical categories:

Evidence Based Medicine Research for Pelizaeus-Merzbacher Disease

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Pelizaeus-Merzbacher Disease: Animations

Prognosis for Pelizaeus-Merzbacher Disease

Prognosis for Pelizaeus-Merzbacher Disease: The prognosis for those with Pelizaeus-Merzbacher disease is poor. The course of the disorder is usually progressive deterioration until death. (Source: excerpt from NINDS Pelizaeus-Merzbacher Disease Information Page: NINDS)

Research about Pelizaeus-Merzbacher Disease

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Statistics for Pelizaeus-Merzbacher Disease

Pelizaeus-Merzbacher Disease: Broader Related Topics

Pelizaeus-Merzbacher Disease Message Boards

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Article Excerpts about Pelizaeus-Merzbacher Disease

Pelizaeus-Merzbacher disease is a rare, progressive, degenerative central nervous system disorder in which coordination, motor abilities, and intellectual function deteriorate. The disease is one of a group of genetic disorders called the leukodystrophies that affect growth of the myelin sheath, the fatty covering--which acts as an insulator--on nerve fibers in the brain. (Source: excerpt from NINDS Pelizaeus-Merzbacher Disease Information Page: NINDS)

Definitions of Pelizaeus-Merzbacher Disease:

A dysmyelinating disorder of the central nervous system associated with a decrease in all myelin proteins, especially proteolipid protein. Several types are recognized: acute infantile types Synonyms: familial chronic infantile diffuse sclerosis perinatal sudanophilic leukodystrophy chronic infantile diffuse cerebral sclerosis adult-onset leukodystrophy Synonyms: late-onset type multiple sclerosis-like disorder autosomal dominant Pelizaeus-Merzbacher disease Pelizaeus-Merzbacher-like disease (PMLD) Synonym: Pelizaeus-Medrzbacher disease with normal proteolipid protein In its classical form, the disease has an onset in the first three months of life with nystagmus followed by slowly progressive psychomotor retardation, involuntary movements, ataxia, and death in the second decade of life. The chronic infantile type may begin as early as the eight day of life and is slowly progressive so that the patient may survive to middle age. The early symptoms include rotary movements of the head and eyes, which may vanish later in life, usually followed by spasticity of the legs and arms, cerebellar ataxia, dementia, and parkinsonian tremor. The adult form has its onset in the fourth or fifth decades and is marked mainly by cerebellar, autonomic, and pyramidal disorders. Urinary and rectal incontinence, orthostatic hypotension, and progressive spasticity are the main symptoms. Pelizaeus-Merzbacher-like disease is marked by symptoms characteristic of the classical form in, but with normal myelin which, however, is arranged into ball-like structures in the oligodendrocyte perikarya and terminal processes. - (Source - Diseases Database)

Pelizaeus-Merzbacher Disease is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH). This means that Pelizaeus-Merzbacher Disease, or a subtype of Pelizaeus-Merzbacher Disease, affects less than 200,000 people in the US population.
Source - National Institutes of Health (NIH)

Ophanet, a consortium of European partners, currently defines a condition rare when it affects 1 person per 2,000. They list Pelizaeus-Merzbacher Disease as a "rare disease".
Source - Orphanet

 

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