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Diseases » Polycystic kidney disease » Inheritance

Inheritance and Genetics of Polycystic kidney disease

Genetics of Polycystic kidney disease:

Most types of polycystic kidney disease are inherited in an autosomal dominant pattern, although a more rare type is inherited in an autosomal recessive pattern.

Polycystic kidney disease: Genetics Information

Genetics of Polycystic kidney disease: In 1994 the European Polycystic Kidney Disease Consortium isolated a gene from chromosome 16 that was disrupted in a family with APCD. The protein encoded by the PKD1 gene is an integral membrane protein involved in cell-cell interactions and cell-matrix interactions. The role of PKD1 in the normal cell may be linked to microtubule-mediated functions, such as the placement of Na(+), K(+)-ATPase ion pumps in the membrane. Programmed cell death, or apoptosis, may also be invoked in APKD. Further clarification of the pathogenesis of the disease await further research. (Source: Genes and Disease by the National Center for Biotechnology)

About inheritance and genetics:

Inheritance of Polycystic kidney disease refers to whether the condition is inherited from your parents or "runs" in families. The level of inheritance of a condition depends on how important genetics are to the disease. Strongly genetic diseases are usually inherited, partially genetic diseases are sometimes inherited, and non-genetic diseases are not inherited. For general information, see Introduction to Genetics.


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