Cure Research for Sickle Cell Anemia

Cure Research list for Sickle Cell Anemia:

The list of research areas and treatments under analysis mentioned in various sources for Sickle Cell Anemia includes:

• Fetal hemoglobin stimulants
  • Hydroxyurea (HU) - a promising treatment for SCA.
  • Hydroxyurea and erythropoietin combination
  • Butyrate
• Clotrimazole
• Bone marrow transplantation
• Gene therapy

Curable Types of Sickle Cell Anemia

Possibly curable or rare types of Sickle Cell Anemia include:

• Infectious crisis of sickle cell anemia
• Vaso-occlusive crisis of sickle cell anemia
• Septic arthritis due to sickle cell anemia
• more curable types...»

Rare Types of Sickle Cell Anemia:

Some rare types of Sickle Cell Anemia include:

• Bone marrow toxins( phenylbutazone) induced sickle cell anemia
• Rib infarction induced by sickle cell anemia
• Synovial thrombosis caused by sickle cell anemia
• more rare types...»

Treatments for Sickle Cell Anemia

Treatments to consider for Sickle Cell Anemia may include:

• Preventive antibiotics
• Preventive penicillin - especially for newborns, infants and children with SCA.
• Pain crisis treatments
  • Pain-killing drugs
  • Fluids
• Blood transfusions
• more treatments...»

Cure Research discussion for Sickle Cell Anemia:

Genes and Disease by the National Center for Biotechnology (Excerpt)

A mouse model of SCA has been developed and is being used to evaluate the effectiveness of potential new therapies for SCA. (Source: Genes and Disease by the National Center for Biotechnology)

Hydroxyurea in Pediatric Patients with Sickle Cell Disease: NHLBI (Excerpt)

A Phase I/II study ( PED-HUG) was supported by the NHLBI to determine the therapeutic dose of hydroxyurea in children with 3 or more painful episodes per year and to identify any short-term toxicities. (Source: excerpt from Hydroxyurea in Pediatric Patients with Sickle Cell Disease: NHLBI)

NHLBI, Fact Sheet Multicenter Study of Hydroxyurea for Sickle Cell Anemia: NHLBI (Excerpt)

Several other drugs under investigation (erythropoietin, butyrate and related compounds) may work together with hydroxyurea to make it more effective, but those studies are still in progress. Bone marrow transplantation can really cure the disease, but the risks are high, and only a small number of young patients are good candidates for that form of experimental therapy. Some day gene therapy may provide a safe and effective cure, and that will be some years in the future. (Source: excerpt from NHLBI, Fact Sheet Multicenter Study of Hydroxyurea for Sickle Cell Anemia: NHLBI)

Medical research for Sickle Cell Anemia: medical news summaries:

The following medical news items are relevant to medical research for Sickle Cell Anemia:

• Viagra provides significant benefits for sickle cell anemia patients with secondary pulmonary hypertension
• More news »

Clinical Trials for Sickle Cell Anemia

Some of the clinical trials for Sickle Cell Anemia include:

• A Study of the Efficacy and Safety of ICA-17043 (With or Without Hydroxyurea) in Patients With Sickle Cell Anemia. - This study has been completed (Current: 23 Nov 2006) - ICA-17043
• A Study Evaluating the Long-Term Safety of ICA-17043 in Sickle Cell Disease Patients With or Without Hydroxyurea Therapy - This study is currently recruiting patients (Current: 23 Nov 2006) - ICA-17043
• Nitric Oxide Inhalation to Treat Sickle Cell Pain Crises - This study is currently recruiting patients (Current: 23 Nov 2006) - Nitric Oxide,INO Pulse/NO Delivery System
• Trial of Oral Glutamine in Patients With Sickle Cell Anemia - This study is currently recruiting patients (Current: 23 Nov 2006) - Glutamine
• Use of Hydroxyurea and Magnesium Pidolate for Treatment of Sickle Cell Disease - This study is no longer recruiting patients (Current: 23 Nov 2006) - Magnesium Pidolate, Hydroxyurea
• more trials...»

Evidence Based Medicine Research for Sickle Cell Anemia

Medical research papers related to Sickle Cell Anemia include:

• Hematopoietic stem cell transplantation for children with sickle cell disease
• Antibiotics for treating osteomyelitis in people with sickle cell disease
• Treatments for priapism in boys and men with sickle cell disease
• Interventions for treating painful sickle cell crisis during pregnancy
• Sickle cell disease
• Antibiotics for treating acute chest syndrome in people with sickle cell disease
• Splenectomy versus conservative management for acute sequestration crises in people with sickle cell disease
• Pneumococcal vaccines for sickle cell disease
• Hydroxyurea for sickle cell disease
• Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease
• Piracetam for reducing the incidence of painful sickle cell disease crises
• Inhaled nitric oxide for acute chest syndrome in people with sickle cell disease
• Hydroxyurea for the treatment of sickle cell disease
• Carrier screening for Thalassemia and hemoglobinopathies in Canada
• Hydroxyurea Treatment for Sickle Cell Disease
• National Institutes of Health Consensus Development Conference statement: hydroxyurea treatment for sickle cell disease.
• Neonatal screening for sickle cell disease
• Hydroxyurea for sickle cell disease: a systematic review for efficacy and toxicity in children
• Evolution of novel small-molecule therapeutics targeting sickle cell vasculopathy.
• Birthweights in sickle cell trait pregnancies
• Inhaled bronchodilators for acute chest syndrome in people with sickle cell disease
• Blood transfusion for preventing stroke in people with sickle cell disease
• Sickle cell disease
• Sickle Cell Trait Is Associated with a Delayed Onset of Malaria: Implications for Time-to-Event Analysis in Clinical Studies of Malaria
• Fluid replacement therapy for acute episodes of pain in people with sickle cell disease
• An Evidence-based Review for the NIH Consensus Development Conference on Hydroxyurea for the Treatment of Adults with Sickle Cell Disease.
• Hydroxyurea Treatment of Sickle Cell Disease
• Can a Levonorgestrel-releasing intrauterine system (LNG-IUS)be used in a woman currently on tacrolimus and prednisolone following renal transplant secondary to sickle cell disease and is there a need to use prophylactic antibiotics?
• Daily assessment of pain in adults with sickle cell disease.
• Hydroxyurea for the treatment of sickle cell disease

Click here to find more evidence-based articles on the TRIP Database

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