Clinical Trials for Spinal conditions
Clinical trials are research studies conducted in an effort to improve overall patient health and care.
Each trial involves running supervised tests to determine the effectiveness and safety of new drugs, procedures and/or devices with the aim of answering scientific questions about a disease or condition.
Risks and side-effects are also evaluated during these trials with results ranging from being unpleasant, with side effects such as headaches, to more serious or even life-threatening risks.
A clinical trial may be separated into phases, or steps, with each step designed to answer a separate research question. This maybe reflected in the trial name.
A brief description of each phase:
- Phase I: Usually designed to evaluate safety, determine a safe dosage range, and identify side effects on a small group of patients.
- Phase II: If Phase I is successful, the trial is then repeated with a larger group to further evaluate its effect and safety.
- Phase III: Trials are conducted on an ever larger group and are compared with the best current treatment while gathering more information on effect and safety.
- Phase IV: These studies monitor long-term side effects after the treatment has been marketed.
Clinical Trials data for Spinal conditions is grouped into the following categories:-
The format for each of the following is:
- The name of the trial,
- followed by whether the trial is recruiting patients,
- The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
- Note**: Please follow the link to determine the current trial status.
- followed by a list of drug/s, if any, used in the trial
ClinicalTrials.gov has listed the following trials for Spinal conditions:
- Safety and Effectiveness Study of Prodisc to Spinal Fusion Surgery - This study is no longer recruiting patients (Current: 23 Nov 2006)
- Comparing Two Instrumentation Systems for the Treatment of Adolescent Scoliosis - This study has been completed (Current: 23 Nov 2006)
- Surgical Versus Nonsurgical Treatment for Spinal Stenosis - This study is no longer recruiting patients (Current: 23 Nov 2006)
- Spine Patient Outcomes Research Trial (SPORT): Degenerative Spondylolisthesis With Spinal Stenosis - This study has been completed (Current: 23 Nov 2006)
- Spine Patient Outcomes Research Trial (SPORT) - Intervertebral Disc Herniation - This study has been completed (Current: 23 Nov 2006)
- Spine Patient Outcomes Research Trial (SPORT): Spinal Stenosis - This study has been completed (Current: 23 Nov 2006)
- Prevention of Arthritis-Related Work Disability - This study has been completed (Current: 23 Nov 2006)
- Blocking Tumor Necrosis Factor in Ankylosing Spondylitis - This study has been completed (Current: 23 Nov 2006) - Anti-Tumor Necrosis Factor
- Genetic and Immune Studies of Rheumatoid Arthritis and Related Conditions - This study has been completed (Current: 23 Nov 2006)
- The Pathogenesis of Inflammatory Synovitis: A Study of Early Arthritis - This study has been completed (Current: 23 Nov 2006)
- Direct Injection of Alcohol for the Treatment of Spinal Tumors - This study has been completed (Current: 23 Nov 2006)
- Study of Psoriatic Arthritis - This study has been completed (Current: 23 Nov 2006)
- A Controlled Trial of Intermittent Fludarabine for Psoriatic Arthritis - This study has been completed (Current: 23 Nov 2006)
- Prognostic Indicators and Determinants of the 2-5 Year Outcome in a Cohort of Early Synovitis Patients - This study has been completed (Current: 23 Nov 2006)
- Phase II Pilot Study of Olsalazine for Ankylosing Spondylitis - This study has been completed (Current: 23 Nov 2006) - olsalazine
- Low-Dose Radiation to Prevent Complications of Back Surgery - This study has been completed (Current: 23 Nov 2006)
- Impact of Literacy Level on Patient Education and Health Among People With Arthritis - This study is no longer recruiting patients (Current: 23 Nov 2006)
- A Study of the Safety and Efficacy of Infliximab (Remicade) in Patients With Psoriatic Arthritis - This study has been completed (Current: 23 Nov 2006) - Infliximab
- Safety, Efficacy and Pharmacokinetics of an Antibody for Psoriatic Arthritis - This study has been completed (Current: 23 Nov 2006) - efalizumab
- Genetic Determinants of Ankylosing Spondylitis Severity - Longitudinal Study - This study is currently recruiting patients (Current: 23 Nov 2006)
- Genetic Determinants of Ankylosing Spondylitis Severity - This study is currently recruiting patients (Current: 23 Nov 2006)
- Genetics of Ankylosing Spondylitis - This study is currently recruiting patients (Current: 23 Nov 2006)
- Human Anti-TNF Monoclonal Antibody Adalimumab in Subjects With Active Ankylosing Spondylitis - This study is no longer recruiting patients (Current: 23 Nov 2006) - Adalimumab (D2E7)
- Progression of Spinal Fusion in Ankylosing Spondylitis - This study is currently recruiting patients (Current: 23 Nov 2006)
- Onercept in the Treatment and Re-Treatment of Subjects With Moderate to Severe Plaque Psoriasis - This study has been terminated (Current: 23 Nov 2006) - Onercept (r-hTBP-1)
- Lumbar Interbody Fusion Using the Telamon Peek Versus the Telamon Hydrosorb Fusion Device - This study is currently recruiting patients (Current: 23 Nov 2006)
- Study of REN-1654 in Patients With Sciatica Pain - This study is no longer recruiting patients (Current: 23 Nov 2006) - REN-1654
- Greenwich Lumbar Stenosis SLIP Study - This study is currently recruiting patients (Current: 23 Nov 2006)
- Nucleoplasty for Contained Herniated Lumbar Discs - This study is currently recruiting patients (Current: 23 Nov 2006)
- Study of Intra-Articular Delivery of tgAAC94 in Inflammatory Arthritis Subjects - This study is currently recruiting patients (Current: 23 Nov 2006)
- REPArE: Rating Evaluations in Psoriatic Arthritis (PsA) With Enbrel - This study is currently recruiting patients (Current: 23 Nov 2006) - Enbrel®
- TNFalfa Blocking Treatment of Spondylarthropathies - This study is currently recruiting patients (Current: 23 Nov 2006) - Infliximab,Etanercept,Adalimumab
- Effects of Lateral Trunk Support on Spinal Alignment in Spinal Cord Injured Persons - This study has been completed (Current: 23 Nov 2006)
- Study Evaluating Etanercept and Methotrexate in Plaque Psoriasis - This study is currently recruiting patients (Current: 23 Nov 2006) - Etanercept,Methotrexate
- Comparison of IDD Therapy and Non-Surgical Treatment for Low Back Pain Caused by Degenerative Disc Disease - This study is no longer recruiting patients (Current: 23 Nov 2006)
- HDAC Activity in Peripheral Skeletal Muscle in COPD - This study is currently recruiting patients (Current: 23 Nov 2006)
- Study Investigating Enbrel Treatment for Ankylosing Spondylitis - This study is currently recruiting patients (Current: 23 Nov 2006) - Enbrel
- Safety and Efficacy of Adalimumab in Patients With Moderate to Severely Active Psoriatic Arthritis - This study is no longer recruiting patients (Current: 23 Nov 2006)
- Safety and Efficacy of Adalimumab in Patients With Active Ankylosing Spondylitis - This study is currently recruiting patients (Current: 23 Nov 2006) - Adalimumab
- A Study of the Effectiveness of Low-Dose Infliximab for Treatment of Ankylosing Spondylitis (Study P04352) - This study is currently recruiting patients (Current: 23 Nov 2006) - infliximab
- Clinical Outcome Study of the Triad Allograft for Posterior Lumbar Fusion - This study is currently recruiting patients (Current: 23 Nov 2006)
- A Study of Infliximab (Remicade) in Patients With Ankylosing Spondylitis. - This study is no longer recruiting patients (Current: 23 Nov 2006) - infliximab
- Test-Retest Reliability of Pulmonary Function Tests in Patients With Duchenne's Muscular Dystrophy - This study is currently recruiting patients (Current: 23 Nov 2006)
- CHARIT Artificial Disc Compared to Anterior Interbody Fusion for Treatment of Degenerative Disc Disease - This study has been completed (Current: 23 Nov 2006)
- Titanium Surgical Mesh and MOSS-Miami Screws for Lumbar Fusion. - This study is no longer recruiting patients (Current: 23 Nov 2006)
- CHARITE vs. ALIF 5-Year Follow-up - This study is currently recruiting patients (Current: 23 Nov 2006)
- The RATIO: Registry of Infections and Lymphoma in Patients Treated With TNF-a Antagonists - This study is currently recruiting patients (Current: 23 Nov 2006) - TNF-alpha antagonists
- Study Evaluating Enbrel (Etanercept) in Patients With Ankylosing Spondylitis - This study is currently recruiting patients (Current: 23 Nov 2006)
- D2E7-Early AS - This study is no longer recruiting patients (Current: 23 Nov 2006) - Adalimumab 40 mg sc every other week
- Safety and Efficacy Study of Adalimumab in Patients With Active Psoriatic Arthritis (PsA) - This study is no longer recruiting patients (Current: 23 Nov 2006) - adalimumab
- Examination of Radiographic Progression, Efficacy and Safety of Long-Term Treatment With Infliximab in Patients With Ankylosing Spondylitis - This study is currently recruiting patients (Current: 23 Nov 2006) - infliximab
- hOKT3gamma1 (Ala-Ala) for the Treatment of Psoriatic Arthritis - This study is currently recruiting patients (Current: 23 Nov 2006) - hOKT3gamma1 (Ala-Ala)
- Methotrexate in Ankylosing Spondylitis (MTX in AS) - This study is no longer recruiting patients (Current: 23 Nov 2006) - Methotrexate
- Prednisolone in Active Ankylosing Spondylitis (AS) - This study is currently recruiting patients (Current: 23 Nov 2006) - Prednisolon
- New Immunomodulatory Therapy Strategies in Chronic Reactive Arthritis - This study is currently recruiting patients (Current: 23 Nov 2006) - interferon-gamma,infliximab,dmard
- Study Evaluating Etanercept on Skin and Joint Disease in Psoriatic Arthritis - This study is currently recruiting patients (Current: 23 Nov 2006) - Etanercept
- Study Evaluating Etanercept and Sulphasalazine in Ankylosing Spondylitis - This study is currently recruiting patients (Current: 23 Nov 2006) - etanercept,sulphasalazine
- Vertebral Osteosynthesis in Degenerative Lumbar Stenosis With Spondylolisthesis - CLEOS Study - This study is currently recruiting patients (Current: 23 Nov 2006)
- Effectiveness of Bracing in Preventing Scoliosis in Children With Spinal Cord Injury - This study is currently recruiting patients (Current: 23 Nov 2006)
- A Study of the Safety and Efficacy of Golimumab in Subjects With Active Ankylosing Spondylitis - This study is currently recruiting patients (Current: 23 Nov 2006) - Golimumab (CNTO 148)
- A Study of the Safety and Efficacy of Golimumab in Patients With Active Psoriatic Arthritis - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - Golimumab (CNTO 148)
- A Study of the Safety and Efficacy of CNTO 1275 in Patients With Active Psoriatic Arthritis - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - CNTO 1275, monoclonal antibody to IL-12p40 and IL-23 p40 subunits
- Chiropractic Prone Distraction for Lower Back Pain - This study is currently recruiting patients (Current: 23 Nov 2006)
- Study Evaluating Etanercept in Rheumatoid Arthritis, Ankylosing Spondylitis and Psoriatic Arthritis - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - etanercept
- Kineflex Artificial Disc System to Treat DDD - This study is currently recruiting patients (Current: 23 Nov 2006)
- Study Evaluating the Safety and Efficacy of Etanercept in Patients With Psoriatic Arthritis Treated by Dermatologists - This study is currently recruiting patients (Current: 23 Nov 2006) - Etanercept
- Study Evaluating the Safety and Efficacy of Etanercept in Patients With Psoriatic Arthritis Treated by Rheumatologists - This study is currently recruiting patients (Current: 23 Nov 2006) - Etanercept
- Methotrexate in the Treatment of Axial Spondyloarthritis - This study is currently recruiting patients (Current: 23 Nov 2006) - Methotrexate
- Radiofrequency Nucleoplasty Vs Percutaneous Nucleotomy (Dekompressor) Vs Decompression Catheter for the Treatment of Painful Contained Lumbar Disc Herniation - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
- Assessment of P-15 Bone Putty in Anterior Cervical Fusion With Instrumentation - This study is currently recruiting patients (Current: 23 Nov 2006)
- Safety and Efficacy Study of Healos as a Bone Replacement to Treat Degenerative Disc Disease - This study is currently recruiting patients (Current: 23 Nov 2006)
- Double-Blind, Randomized, Placebo-Controlled Phase 3 Study of Etanercept in the Treatment of Psoriatic Arthritis and Psoriasis - This study has been completed (Current: 23 Nov 2006) - Etanercept
- Epsilon-Aminocaproaic Acid to Reduce the Need for Blood Transfusions During and Following Spine Surgery - This study is no longer recruiting patients (Current: 23 Nov 2006) - Epsilon-Aminocaproic Acid (EACA)
- Comparison of the ProAdjuster Analysis to the Penning Method of Determining Intersegmental Motion of the Cervical Spine - This study is currently recruiting patients (Current: 23 Nov 2006)
- Recombinant Human Erythropoietin Compared to Autologous Pre-Donation Prior to Scoliosis Surgery in Children. - This study is currently recruiting patients (Current: 23 Nov 2006)
- ASAS Classification and Diagnostic Criteria for Early SpA - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
- Combination Antibiotic Treatment for Reactive Arthritis Caused by Chlamydia Bacteria - This study is currently recruiting patients (Current: 23 Nov 2006) - Doxycycline and rifampin,Azithromycin and rifampin
- Analgetic and Anxiolytic Effect of Preoperative Pregabalin - This study is currently recruiting patients (Current: 23 Nov 2006) - pregabalin
- 16.0040 Ankylosing Spondylitis Study - This study is no longer recruiting patients (Current: 23 Nov 2006) - Etanercept
- Study to Evaluate the Incidence of Gastric Ulcers Following Administration of Either PN 200 or Naproxen in Subjects Who Are at Risk for Developing NSAID-Associated Ulcers. - This study is currently recruiting patients (Current: 23 Nov 2006) - PN 200 tablets (500 mg naproxen and 20 mg omeprazole),Naproxen 500 mg tablets (PN 200 minus omeprazole)
- Remicade Study in Psoriatic Arthritis Patients Of Methotrexate-Nave Disease (RESPOND) (Study P04422) - This study is currently recruiting patients (Current: 23 Nov 2006) - Infliximab + methotrexate vs. methotrexate alone
- Kineflex-C Artificial Disc System to Treat Cervical DDD - This study is currently recruiting patients (Current: 23 Nov 2006)
- Referral Recommendations for Axial Spondyloarthritis - This study is currently recruiting patients (Current: 23 Nov 2006)
- LDR Spine USA Mobi-C(R) Cervical Disc Prosthesis IDE - This study is currently recruiting patients (Current: 23 Nov 2006)
- Disc Prosthesis Versus Multidisciplinary Rehabilitation - This study is currently recruiting patients (Current: 23 Nov 2006)
- Study of a Facet Replacement to Treat Spinal Stenosis - This study is currently recruiting patients (Current: 23 Nov 2006)
- Efficacy and Safety Study to Evaluate Gadovist (Gadobutrol) as Contrast Agent in Magnetic Resonance Imaging (MRI) of Brain or Spine Diseases in Chinese Patients - This study is currently recruiting patients (Current: 23 Nov 2006) - Gadobutrol
The format for each of the following is:
- The drug,
- followed by the name of the trial,
- followed by whether the trial is recruiting patients,
- The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
- Note**: Please follow the link to determine the current trial status.
ClinicalTrials.gov has listed the following drugs in trials for Spinal conditions:
The trial data on this page has been sourced from
