A very rare autoimmune disorder of the central nervous system causing various symptoms, but also sometimes diabetes. The patient usually has anti-GAD antibodies, and about half get a type of secondary diabetes from SMS. ...more »
See full list of 21 symptoms of Stiff-Person Syndrome
See full list of 7 treatments for Stiff-Person Syndrome
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Prognosis for Stiff-Person Syndrome: There is no cure for stiff-person syndrome. The long-term prognosis for individuals with stiff-person syndrome is uncertain. Management of the disorder with drug therapy may provide significant improvements and relief of symptoms. (Source: excerpt from NINDS Stiff-Person Syndrome Information Page: NINDS)
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Stiff-person syndrome is a rare progressive neurological disorder characterized by constant painful contractions and spasms of voluntary muscles, particularly the muscles of the back and upper legs. (Source: excerpt from NINDS Stiff-Person Syndrome Information Page: NINDS)
A condition characterized by persistent spasms (SPASM) involving multiple muscles, primarily in the lower limbs and trunk. The illness tends to occur in the fourth to sixth decade of life, presenting with intermittent spasms that become continuous. Minor sensory stimuli, such as noise and light touch, precipitate severe spasms. Spasms do not occur during sleep and only rarely involve cranial muscles. Respiration may become impaired in advanced cases. (Adams et al., Principles of Neurology, 6th ed, p1492; Neurology 1998 Jul;51(1):85-93) - (Source - Diseases Database)
Stiff-Person Syndrome is listed as a "rare disease" by the Office of
Rare Diseases (ORD) of the National Institutes of Health
(NIH). This means that Stiff-Person Syndrome, or a subtype of Stiff-Person Syndrome,
affects less than 200,000 people in the US population.
Source - National Institutes of Health (NIH)
Ophanet, a consortium of European partners,
currently defines a condition rare when it affects 1 person per 2,000.
They list Stiff-Person Syndrome as a "rare disease".
Source - Orphanet
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