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Diseases » Tangier disease » Inheritance
 

Inheritance and Genetics of Tangier disease

Genetics of Tangier disease:

Tangier disease is an inherited genetic disease.

Tangier disease: Genetics Information

Genetics of Tangier disease: TD is caused by mutations in the ABC1 (ATP-binding cassette) gene on chromosome 9q31. ABC1 codes for a protein that helps rid cells of excess cholesterol. This cholesterol is then picked up by HDL particles in the blood and carried to the liver, which processes the cholesterol to be reused in cells throughout the body. Individuals with TD are unable to eliminate cholesterol from cells, leading to its buildup in the tonsils and other organs. (Source: Genes and Disease by the National Center for Biotechnology)

About inheritance and genetics:

Inheritance of Tangier disease refers to whether the condition is inherited from your parents or "runs" in families. The level of inheritance of a condition depends on how important genetics are to the disease. Strongly genetic diseases are usually inherited, partially genetic diseases are sometimes inherited, and non-genetic diseases are not inherited. For general information, see Introduction to Genetics.

 

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