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What is Tooth and Nail syndrome?

What is Tooth and Nail syndrome?

  • Tooth and Nail syndrome: A syndrome that is characterized by the occurrence of nail dysplasia and tooth abnormalities. Primary teeth are usually normal but some secondary teeth may be missing. The toenails tend to be more affected than the fingernails.

Tooth and Nail syndrome is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH). This means that Tooth and Nail syndrome, or a subtype of Tooth and Nail syndrome, affects less than 200,000 people in the US population.
Source - National Institutes of Health (NIH)

Ophanet, a consortium of European partners, currently defines a condition rare when it affects 1 person per 2,000. They list Tooth and Nail syndrome as a "rare disease".
Source - Orphanet

Tooth and Nail syndrome: Introduction

Types of Tooth and Nail syndrome:

Broader types of Tooth and Nail syndrome:

How serious is Tooth and Nail syndrome?

Prognosis of Tooth and Nail syndrome: The condition is essentially harmless and the symptoms may be very mild in some cases. Most patients end up with reasonably normal nails in adulthood and the main concern is that appropriate dental management is undertaken.
Complications of Tooth and Nail syndrome: see complications of Tooth and Nail syndrome

What causes Tooth and Nail syndrome?

Causes of Tooth and Nail syndrome: see causes of Tooth and Nail syndrome

What are the symptoms of Tooth and Nail syndrome?

Symptoms of Tooth and Nail syndrome: see symptoms of Tooth and Nail syndrome

Complications of Tooth and Nail syndrome: see complications of Tooth and Nail syndrome

Onset of Tooth and Nail syndrome: Symptoms usually become evident during childhood.

Can anyone else get Tooth and Nail syndrome?

More information: see contagiousness of Tooth and Nail syndrome
Inheritance: see inheritance of Tooth and Nail syndrome

Tooth and Nail syndrome: Testing

Misdiagnosis: see misdiagnosis and Tooth and Nail syndrome.

How is it treated?

Doctors and Medical Specialists for Tooth and Nail syndrome: Medical Geneticist ; see also doctors and medical specialists for Tooth and Nail syndrome.
Treatments for Tooth and Nail syndrome: see treatments for Tooth and Nail syndrome

Name and Aliases of Tooth and Nail syndrome

Main name of condition: Tooth and Nail syndrome

Other names or spellings for Tooth and Nail syndrome:

Hypodontia - nail dysgenesis, Witkops tooth and nail syndrome, Hypodontia [nail dysgenesis], Witkop syndrome

Witkop's syndrome Source - Diseases Database

Witkop syndrome, Dysplasia of nails with hypodontia, TNS
Source - Office of Rare Diseases (ORD) of the National Institutes of Health (NIH)

Tooth and Nail syndrome: Related Conditions

Research the causes of these diseases that are similar to, or related to, Tooth and Nail syndrome:

 

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