Clinical Trials for Toxemia

Clinical trials are research studies conducted in an effort to improve overall patient health and care. Each trial involves running supervised tests to determine the effectiveness and safety of new drugs, procedures and/or devices with the aim of answering scientific questions about a disease or condition. Risks and side-effects are also evaluated during these trials with results ranging from being unpleasant, with side effects such as headaches, to more serious or even life-threatening risks. A clinical trial may be separated into phases, or steps, with each step designed to answer a separate research question. This maybe reflected in the trial name.

A brief description of each phase:

• Phase I: Usually designed to evaluate safety, determine a safe dosage range, and identify side effects on a small group of patients.
• Phase II: If Phase I is successful, the trial is then repeated with a larger group to further evaluate its effect and safety.
• Phase III: Trials are conducted on an ever larger group and are compared with the best current treatment while gathering more information on effect and safety.
• Phase IV: These studies monitor long-term side effects after the treatment has been marketed.

Clinical Trials data for Toxemia is grouped into the following categories:-

• View by trial name
• View by drugs used in Toxemia clinical trials

Clinical Trials by trial name

The format for each of the following is:

• The name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.
• followed by a list of drug/s, if any, used in the trial

ClinicalTrials.gov has listed the following trials for Toxemia:

• Predicting Complications in Women With Toxaemia - This study is currently recruiting patients (Current: 23 Nov 2006)
• Treatment Targets for Chronic Hypertension in Pregnancy - This study is currently recruiting patients (Current: 23 Nov 2006) - methyldopa,labetalol,nifedipine,clonidine
• Calcium for Pre-Eclampsia Prevention (CPEP) - This study has been completed (Current: 23 Nov 2006) - calcium
• Oral Calcium in Pregnant Women With Hypertension - This study has been completed (Current: 23 Nov 2006) - calcium
• Regulation of Placental Vascular Reactivity in Pregnancy-Induced Hypertension - This study has been completed (Current: 23 Nov 2006)
• Renin and Prorenin in Pregnancy - This study has been completed (Current: 23 Nov 2006)
• Effect of Selective iNOS Inhibition During Human Endotoxemia - This study has been completed (Current: 23 Nov 2006) - Aminoguanidine,endotoxin
• Blockade of Vascular Potassium Channels During Human Endotoxemia - This study has been completed (Current: 23 Nov 2006) - endotoxin,Potassium channel blockers: TEA, Quinin, Tolbutamide,L-NMMA
• Low-Dose Endotoxemia and the Acute Phase Response - This study is no longer recruiting patients (Current: 23 Nov 2006) - E. Coli endotoxin
• Pathophysiology and Clinical Relevance of Endotoxin Tolerance in Humans - This study is currently recruiting patients (Current: 23 Nov 2006) - repeated injections of endotoxin during 5 days
• Ethnic Differences in the Inflammatory Response in Systemic Inflammation - This study is currently recruiting patients (Current: 23 Nov 2006) - LPS
• Anti-Inflammatory Effect of Statins in the Human Endotoxemia Model - This study is currently recruiting patients (Current: 23 Nov 2006) - LPS 2ng/kg intravenous bolus,Simvastatin 80mg; administered daily p.o. over 5 days,Rosuvastatin 40mg; administered daily p.o. over 5 days
• Cerebral Blood Flow and Metabolism During Hypoxia and Endotoxemia - This study is currently recruiting patients (Current: 23 Nov 2006)

Drugs used in Clinical Trials for Toxemia

The format for each of the following is:

• The drug,
• followed by the name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.

ClinicalTrials.gov has listed the following drugs in trials for Toxemia:

• Aminoguanidine - Effect of Selective iNOS Inhibition During Human Endotoxemia - This study has been completed (Current: 23 Nov 2006)
• Calcium - Calcium for Pre-Eclampsia Prevention (CPEP) - This study has been completed (Current: 23 Nov 2006)
• Calcium - Oral Calcium in Pregnant Women With Hypertension - This study has been completed (Current: 23 Nov 2006)
• Clonidine - Treatment Targets for Chronic Hypertension in Pregnancy - This study is currently recruiting patients (Current: 23 Nov 2006)
• E. Coli endotoxin - Low-Dose Endotoxemia and the Acute Phase Response - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Endotoxin - Blockade of Vascular Potassium Channels During Human Endotoxemia - This study has been completed (Current: 23 Nov 2006)
• Endotoxin - Effect of Selective iNOS Inhibition During Human Endotoxemia - This study has been completed (Current: 23 Nov 2006)
• L-NMMA - Blockade of Vascular Potassium Channels During Human Endotoxemia - This study has been completed (Current: 23 Nov 2006)
• LPS 2ng/kg intravenous bolus - Anti-Inflammatory Effect of Statins in the Human Endotoxemia Model - This study is currently recruiting patients (Current: 23 Nov 2006)
• LPS - Ethnic Differences in the Inflammatory Response in Systemic Inflammation - This study is currently recruiting patients (Current: 23 Nov 2006)
• Labetalol - Treatment Targets for Chronic Hypertension in Pregnancy - This study is currently recruiting patients (Current: 23 Nov 2006)
• Methyldopa - Treatment Targets for Chronic Hypertension in Pregnancy - This study is currently recruiting patients (Current: 23 Nov 2006)
• Nifedipine - Treatment Targets for Chronic Hypertension in Pregnancy - This study is currently recruiting patients (Current: 23 Nov 2006)
• Potassium channel blockers: TEA, Quinin, Tolbutamide - Blockade of Vascular Potassium Channels During Human Endotoxemia - This study has been completed (Current: 23 Nov 2006)
• Repeated Injections Of Endotoxin During 5 Days - Pathophysiology and Clinical Relevance of Endotoxin Tolerance in Humans - This study is currently recruiting patients (Current: 23 Nov 2006)
• Rosuvastatin 40mg; administered daily p.o. over 5 days - Anti-Inflammatory Effect of Statins in the Human Endotoxemia Model - This study is currently recruiting patients (Current: 23 Nov 2006)
• Simvastatin 80mg; administered daily p.o. over 5 days - Anti-Inflammatory Effect of Statins in the Human Endotoxemia Model - This study is currently recruiting patients (Current: 23 Nov 2006)

The trial data on this page has been sourced from

• The U.S. National Library of Medicine (NLM) together with ClinicalTrials.gov

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