Clinical Trials for Traumatic Brain Injury
Clinical trials are research studies conducted in an effort to improve overall patient health and care.
Each trial involves running supervised tests to determine the effectiveness and safety of new drugs, procedures and/or devices with the aim of answering scientific questions about a disease or condition.
Risks and side-effects are also evaluated during these trials with results ranging from being unpleasant, with side effects such as headaches, to more serious or even life-threatening risks.
A clinical trial may be separated into phases, or steps, with each step designed to answer a separate research question. This maybe reflected in the trial name.
A brief description of each phase:
- Phase I: Usually designed to evaluate safety, determine a safe dosage range, and identify side effects on a small group of patients.
- Phase II: If Phase I is successful, the trial is then repeated with a larger group to further evaluate its effect and safety.
- Phase III: Trials are conducted on an ever larger group and are compared with the best current treatment while gathering more information on effect and safety.
- Phase IV: These studies monitor long-term side effects after the treatment has been marketed.
Clinical Trials data for Traumatic Brain Injury is grouped into the following categories:-
The format for each of the following is:
- The name of the trial,
- followed by whether the trial is recruiting patients,
- The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
- Note**: Please follow the link to determine the current trial status.
- followed by a list of drug/s, if any, used in the trial
ClinicalTrials.gov has listed the following trials for Traumatic Brain Injury:
- Evaluation of an Intervention Model for Family Crisis and Support - This study is currently recruiting patients (Current: 23 Nov 2006)
- Proteomics of Brain Trauma-Associated Elevated Intracranial Pressure (ICP) - This study is currently recruiting patients (Current: 23 Nov 2006)
- Comparative Efficacy of Three Preparations of Botox-A in Treating Spasticity - This study is currently recruiting patients (Current: 23 Nov 2006) - Botox-A
- Supporting Traumatic Brain Injury (TBI) Caregivers - This study is no longer recruiting patients (Current: 23 Nov 2006)
- Age of Blood in Brain Injury - This study is currently recruiting patients (Current: 23 Nov 2006)
- Hypothermia to Treat Severe Brain Injury - This study is no longer recruiting patients (Current: 23 Nov 2006)
- Therapy for Reading Problems in Adults After Brain Injury - This study is currently recruiting patients (Current: 23 Nov 2006)
- Magnesium Sulfate For Brain Injury - This study is no longer recruiting patients (Current: 23 Nov 2006) - magnesium sulfate
- Pediatric Traumatic Brain Injury: Methylphenidate Effects on Early Recovery - This study has been completed (Current: 23 Nov 2006) - methylphenidate
- Measuring Head Impacts in Sports - This study is no longer recruiting patients (Current: 23 Nov 2006)
- Therapeutic Hypothermia for Severe Traumatic Brain Injury in Japan - This study is currently recruiting patients (Current: 23 Nov 2006)
- Pharmacological Intervention in Depression After Traumatic Brain Injury - This study is currently recruiting patients (Current: 23 Nov 2006) - Venlafaxine
- Hypertonic Resuscitation Following Traumatic Brain Injury - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - 7.5% Hypertonic Saline in 6% Dextran-70 (HSD),7.5% Hypertonic Saline (HS)
- Magnesium Sulfate to Prevent Brain Injury in Premature Infants - This study is no longer recruiting patients (Current: 23 Nov 2006) - magnesium sulfate
- Study of the Approximate Entropy of Adrenocorticotropic Hormone and Cortisol Secretion in Patients With Head Injury - This study is no longer recruiting patients (Current: 23 Nov 2006) - cosyntropin,metyrapone
- Phase I/II Study of Neuroendocrine Dysfunction in Patients With Closed Head Injuries - This study is no longer recruiting patients (Current: 23 Nov 2006)
- Genotype Influence on Recovery After Traumatic Brain Injury - This study has been completed (Current: 23 Nov 2006)
- Cerebral Hemodynamic Effects of Hypertonic Solutions in Severely Head-Injured Patients - This study is currently recruiting patients (Current: 23 Nov 2006) - Mannitol,Hypertonic Saline
- Vietnam Head Injury Study - Phase III - This study is currently recruiting patients (Current: 23 Nov 2006)
- Outcome Predictors in Acute Brain Injury - This study has been completed (Current: 23 Nov 2006)
- Problem Solving for Caregivers of Persons With Brain Injury - This study is currently recruiting patients (Current: 23 Nov 2006)
- Comparison Between Different Types of Oxygen Treatment Following Traumatic Brain Injury - This study is currently recruiting patients (Current: 23 Nov 2006)
- (NABIS:H) National Acute Brain Injury Study: Hypothermia - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
- Excitatory Amino Acids and Activated Microglia After Traumatic Brain Injury: a (R)-[11C]PK11195 PET Study - This study is no longer recruiting patients (Current: 23 Nov 2006)
- Treatment of Post-TBI Depression - This study is currently recruiting patients (Current: 23 Nov 2006)
- Intrathecal Baclofen Therapy and Paroxysmal Dysautonomia in Severe Brain-Injured Patients - This study has been suspended (Current: 23 Nov 2006) - baclofen (drug)
- Depression and Traumatic Brain Injury - This study is no longer recruiting patients (Current: 23 Nov 2006) - citalopram (celexa)
- Safety of Autologous Stem Cell Treatment for Traumatic Brain Injury in Children - This study is currently recruiting patients (Current: 23 Nov 2006)
- Erythropoietin Effects After Traumatic Brain Injury - This study is currently recruiting patients (Current: 23 Nov 2006) - Erythropoietin administration
- Hypothermia in Traumatic Brain Injury in Children (HiTBIC) - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
- Affect Recognition:Enhancing Performance of Persons With Traumatic Brain Injury - This study is currently recruiting patients (Current: 23 Nov 2006)
- Pilot, Proof-of-Concept Study of Sublingual Tizanidine in Children With Chronic Traumatic Brain Injury (TBI) - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - Sublingual Tizanidine HCl
- A Prospective, Randomized Trial of Early Versus Late Tracheostomy in Trauma Patients With Severe Brain Injury - This study is currently recruiting patients (Current: 23 Nov 2006)
- The Effect of Mild Traumatic Brain Injury on Recovery From Injury - This study is currently recruiting patients (Current: 23 Nov 2006)
- Telerehabilitation for the Hand and Arm After Stroke and Traumatic Brain Injury - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
- Effects of Erythropoietin on Cerebral Vascular Dysfunction and Anemia in Traumatic Brain Injury - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - recombinant human erythropoietin, rhEpo
- The Use of Tissue Oxygen Monitoring in Critically Injured Patients - This study is currently recruiting patients (Current: 23 Nov 2006)
- Anaesthesia With Propofol Versus Midazolam : Effect on Oxidative Stress in the Brain of Head Trauma Patients - This study is currently recruiting patients (Current: 23 Nov 2006) - Propofol
- Acute Cognitive and Neurobehavioral Intervention: Efficacy Evaluation - This study is currently recruiting patients (Current: 23 Nov 2006)
- Efficacy and Safety of Rivastigmine in Patients With Traumatic Brain Injury and Cognitive Impairment - This study is no longer recruiting patients (Current: 23 Nov 2006) - Rivastigmine
- Treatment of Citalopram for Anxiety Disorders Following a Traumatic Brain Injury - This study is currently recruiting patients (Current: 23 Nov 2006) - Citalopram
- The Connection Between Gait Variability Parameters and Balance Performance in Children With Physical Disability - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
- Home Based Exercise Program for Brain Injury Children - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
- Structural Brain Abnormalities in Children Born Prematurely: New Detection Methods and Clinical-Pathological Correlates - This study is currently recruiting patients (Current: 23 Nov 2006)
- The DECRA Trial: Early Decompressive Craniectomy in Patients With Severe Traumatic Brain Injury - This study is currently recruiting patients (Current: 23 Nov 2006)
- Neuropsychiatric Evaluation of Healthy Volunteers and Adults With Schizophrenia - This study has been completed (Current: 23 Nov 2006)
- Antenatal Phenobarbital to Prevent Neonatal Intracranial Hemorrhage - This study has been completed (Current: 23 Nov 2006) - phenobarbital
- The Use of Low Molecular Weight Heparin in Traumatic Brain Injury - This study has been suspended (Current: 23 Nov 2006) - Enoxaparin
- The Erythropoietin NeuroProtective Effect: Assessment in CABG Surgery (TENPEAKS) - This study has been completed (Current: 23 Nov 2006) - Human recombinant erythropoietin
- Progesterone Treatment of Blunt Traumatic Brain Injury - This study is no longer recruiting patients (Current: 23 Nov 2006) - IV Progesterone
- Safety Study of AVP-923 in the Treatment of IEED (Involuntary Emotional Expression Disorder) Also Known as Pseudobulbar Affect (Episodes of Uncontrolled Crying and/or Laughter) - This study is currently recruiting patients (Current: 23 Nov 2006) - AVP-923
- Prospective Memory in Children With Traumatic Brain Injury - This study is currently recruiting patients (Current: 23 Nov 2006)
- Incidence/Magnitude-Haemorrhagic Progression-Cerebral Contusions and Identification (ID) of Safety Issues After Traumatic Brain Injury - This study has been completed (Current: 23 Nov 2006)
- Dexanabinol in Severe Traumatic Brain Injury - This study has been completed (Current: 23 Nov 2006) - Dexanabinol
- Intensive Monitoring of Brain Injured Patients - This study is currently recruiting patients (Current: 23 Nov 2006)
- Spinal Clearance Study: Expediting the Spinal Clearance Process in the Major Trauma Patient - This study is currently recruiting patients (Current: 23 Nov 2006)
- Is Sensory Stimulation Effective in Reducing Time Spent in a Coma or Vegetative State - This study is currently recruiting patients (Current: 23 Nov 2006)
- Effects of Perfluorocarbon Oxygen Delivery in Severe Head Injury - This study is currently recruiting patients (Current: 23 Nov 2006) - Oxycyte infusion
- A Trial of Two On-Line Interventions for Child Brain Injury - This study is currently recruiting patients (Current: 23 Nov 2006)
- Cerebral Perfusion Pressure (CPP) Management Information Feedback and Nursing - This study has been completed (Current: 23 Nov 2006)
- Sertraline vs. Placebo for Symptoms Following Traumatic Brain Injury - This study is currently recruiting patients (Current: 23 Nov 2006) - sertraline
- Phase III Hypothermia Clinical Trial - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
- Monitoring Brain Activity in Human Brain Injury - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
- Neuroendocrine Dysfunction in Traumatic Brain Injury: Correlation With Cognitive Dysfunction and Repair - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
- Checking the Usability of a Virtual Reality System in Children With Brain Injury - This study is currently recruiting patients (Current: 23 Nov 2006)
- Safety of Darbepoetin Alfa Treatment in Patients With Severe Traumatic Brain Injury - This study is currently recruiting patients (Current: 23 Nov 2006) - Darbepoetin alfa - Neuroprotection
- Diffusion-Tensor Magnetic Resonance Imaging (MRI) and the Evaluation of Perinatal Brain Injury - This study is currently recruiting patients (Current: 23 Nov 2006)
- Sodium-Lactate and Traumatic Brain Injury - This study has been terminated (Current: 23 Nov 2006) - Mannitol, Sodium-Lactate
- Improving Executive Functions After TBI: A Randomized Clinical Trial of the Executive Plus Program - This study is currently recruiting patients (Current: 23 Nov 2006)
- Use of Salt-Water Solution to Improve Symptoms in Concussion - This study is currently recruiting patients (Current: 23 Nov 2006) - 3% Hypertonic Saline
- An Extension Study Evaluating the Efficacy and Safety of Rivastigmine in Patients With Traumatic Brain Injury (TBI) With Persistent Cognitive Deficits - This study is no longer recruiting patients (Current: 23 Nov 2006) - Rivastigmine
- Genomics, SNPs, and Clinical Neonatology - This study is currently recruiting patients (Current: 23 Nov 2006)
- Phase III Double Blind Trial of Valproate Sodium for Prophylaxis of Post Traumatic Seizures - This study has been completed (Current: 23 Nov 2006) - phenytoin,valproate sodium
- Prevention of Shaken Baby Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006)
- Safety and Preliminary Efficacy of Recombinant Activated Factor VII in Subjects With Traumatic Brain Injury - This study is no longer recruiting patients (Current: 23 Nov 2006) - Recombinant Activated Factor VII (NovoSeven®/NiaStase®)
- Parents Helping Infants Study: Educational Intervention to Change the Knowledge, Attitudes and Behaviour of New Parents About Early Infant Crying - This study is currently recruiting patients (Current: 23 Nov 2006)
- Intravenous Metoclopramide for the Treatment of Post Concussive Headache: a Randomized Placebo Controlled Trial - This study is currently recruiting patients (Current: 23 Nov 2006) - metoclopramide
- Enteral Glutamine in Neurologically-Injured Patients - This study is currently recruiting patients (Current: 23 Nov 2006) - nutritional supplement,Enteral glutamine powder
- Antidepressant Maintenance in Traumatic Brain Injury - This study is currently recruiting patients (Current: 23 Nov 2006) - Citalopram
- Fitness Training After Traumatic Brain Injury - This study is currently recruiting patients (Current: 23 Nov 2006)
- Phase II Randomized Study of Selective Dorsal Rhizotomy and Physiotherapy Vs Physiotherapy Alone for Spastic Diplegia - This study is no longer recruiting patients (Current: 23 Nov 2006)
- Prospective Studies of the Use of Self Hypnosis, Acupuncture and Osteopathic Manipulation on Muscle Tension in Children With Spastic Cerebral Palsy - This study has been completed (Current: 23 Nov 2006)
- Beneficial Effects of Antenatal Magnesium Sulfate (BEAM Trial) - This study is no longer recruiting patients (Current: 23 Nov 2006) - magnesium sulfate
- Eye-Hand Coordination in Children With Spastic Diplegia - This study has been completed (Current: 23 Nov 2006)
- Botulinum Toxin (BOTOX) for Cerebral Palsy - This study is no longer recruiting patients (Current: 23 Nov 2006) - Botulinum toxin type A
- Constraint-Based Therapy to Improve Motor Function in Children With Cerebral Palsy - This study is currently recruiting patients (Current: 23 Nov 2006)
- Relaxation Training to Decrease Pain and Improve Function in Adolescents With Cerebral Palsy - This study is currently recruiting patients (Current: 23 Nov 2006)
- Classification of Cerebral Palsy Subtypes - This study has been completed (Current: 23 Nov 2006)
- Brain Control of Movements in Cerebral Palsy - This study is currently recruiting patients (Current: 23 Nov 2006)
- Brain Reorganization Following Constraint-Induced Therapy in Children With Cerebral Palsy - This study is no longer recruiting patients (Current: 23 Nov 2006)
- Effects of Walking Analysis on Surgical Outcomes - This study is currently recruiting patients (Current: 23 Nov 2006)
- A Study to Tailor Advance Directives - This study is currently recruiting patients (Current: 23 Nov 2006)
- Hypertonia in Patients With Cerebral Palsy - This study is currently recruiting patients (Current: 23 Nov 2006)
- Botulinum Toxin Efficiency on Spasticity of Rectus Femoris and Semitendinosus Muscles as Functional Agonist and Antagonist Muscles - This study is currently recruiting patients (Current: 23 Nov 2006) - Botulinum toxin
- Alterations of Functional Activities and Leg Stiffness After Hamstring Lengthening in Cerebral Palsy Children - This study has been completed (Current: 23 Nov 2006)
- Treatment of Drooling With Type A Botulinum Toxin in Children With Cerebral Palsy - This study is currently recruiting patients (Current: 23 Nov 2006) - botulinum toxin A injection
- Music Therapy During Botulinum Injections - This study is currently recruiting patients (Current: 23 Nov 2006)
- Project:Intensive Habilitation (PIH) - This study is currently recruiting patients (Current: 23 Nov 2006)
- Post Marketing Surveillance Study of Dysport - This study is no longer recruiting patients (Current: 23 Nov 2006)
- Acupuncture as Complementary Therapy for Cerebral Palsy - This study is currently recruiting patients (Current: 23 Nov 2006)
- Intrathecal Administration of Baclofen (ITB) to Cerebral Palsy Patients With Therapy-Resistant Spasticity - This study is no longer recruiting patients (Current: 23 Nov 2006) - Administration of intrathecal baclofen
- DOES MYOBLOC IMPROVE FUNCTIONAL HAND USE IN YOUNG CHILDREN WITH A HYPERTONIC UPPER EXTREMITY? - This study has been completed (Current: 23 Nov 2006) - Botulinum Toxin type B
- Comparison of Tendon Transfer, Botox Injections and Ongoing Treatment in Hemiplegic Cerebral Palsy - This study is currently recruiting patients (Current: 23 Nov 2006)
- Does Reducing Spasticity Permit an Increase in Strength? - This study is currently recruiting patients (Current: 23 Nov 2006) - baclofen
- Efficacy and Functional Outcomes of Botulinum Toxin A Injections to Hamstrings in Flexed Knee Gait in Cerebral Palsy - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - Botulinum Toxin A
- A Comparative Study of the Effectiveness of Treatment of Contractures With Mechanically Applied Stretch and Heat. - This study is currently recruiting patients (Current: 23 Nov 2006)
- An Evaluation of Hyperbaric Treatments for Children With Cerebral Palsy - This study is currently recruiting patients (Current: 23 Nov 2006)
- The Effects of Electrical Stimulation Gait Training on Walking and Posture for Children With Cerebral Palsy - This study is currently recruiting patients (Current: 23 Nov 2006)
- Vibration Intervention to Improve Bone and Muscle in Children With Cerebral Palsy - This study is no longer recruiting patients (Current: 23 Nov 2006)
- Hand-Arm Bimanual Intensive Therapy (HABIT) for Children With Hemiplegic Cerebral Palsy - This study is currently recruiting patients (Current: 23 Nov 2006)
- Effects of Dynamic Wheelchair Seating on Spasticity and Functional Mobility in Children - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
- Motion Analysis of Sit-to-Stand Movements in Children With Spastic Diplegia - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
- Power Wheelchair Joystick Use in Spastic Cerebral Palsy - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
- Cortical Visual Impairment and Visual Attentiveness - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
- Effect of Protein Composition on Gastric Emptying - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
- OPTIMIZING ASSISTED COMMUNICATION DEVICES FOR CHILDREN WITH MOTOR IMPAIRMENTS USING A MODEL OF INFORMATION RATE AND CHANNEL CAPACITY - This study has been completed (Current: 23 Nov 2006)
- Strength Training Using Neuromuscular Electrical Stimulation For Children With Cerebral Palsy - This study is currently recruiting patients (Current: 23 Nov 2006)
- Dutch National ITB Study in Children With Cerebral Palsy - This study is no longer recruiting patients (Current: 23 Nov 2006) - baclofen,intrathecal
- Impact of Listening to Low Tones on Motor Function in Children With CP - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
- Study of a Stationary Cycling Intervention for Children With Spastic Diplegic Cerebral Palsy - This study is no longer recruiting patients (Current: 23 Nov 2006)
- A Study of Decreased Mental Function Associated With HIV - This study is no longer recruiting patients (Current: 23 Nov 2006) - Selegiline hydrochloride
- Randomized Trial of Hydrocortisone in Very Preterm High-Risk Infants - This study is currently recruiting patients (Current: 23 Nov 2006) - Hydrocortisone
- Post-TBI Fatigue and Its Treatment - This study is currently recruiting patients (Current: 23 Nov 2006) - Modafinil
- Treatment of Post-TBI Depression - This study is currently recruiting patients (Current: 23 Nov 2006) - Sertraline
- Home Stimulation for Brain-Asphyxiated Infants - This study is currently recruiting patients (Current: 23 Nov 2006)
- Effects Of DP-b99 On Neurological Function In Subjects With Acute Ischemic Hemispheric Stroke - This study is currently recruiting patients (Current: 23 Nov 2006) - DP-b99
- Financial and Clinical Impact of Repeal of the Pennsylvania Motorcycle Helmet Law - This study is currently recruiting patients (Current: 23 Nov 2006)
- Body Cooling for Birth Asphyxia in Term Infants - This study is no longer recruiting patients (Current: 23 Nov 2006)
- Umbilical Cord Blood Proteomic Analysis and Neonatal Brain Injury - This study is currently recruiting patients (Current: 23 Nov 2006)
- Prevalence of Delirium in Patients Undergoing Cardiac Surgery - This study is currently recruiting patients (Current: 23 Nov 2006)
- Neuropathology of Spasmodic Dysphonia - This study is currently recruiting patients (Current: 23 Nov 2006)
The format for each of the following is:
- The drug,
- followed by the name of the trial,
- followed by whether the trial is recruiting patients,
- The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
- Note**: Please follow the link to determine the current trial status.
ClinicalTrials.gov has listed the following drugs in trials for Traumatic Brain Injury:
The trial data on this page has been sourced from
