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Tropical Spastic Paraparesis

Tropical Spastic Paraparesis: Introduction

Tropical Spastic Paraparesis: For several decades the term “tropical spastic paraparesis” (TSP) was used to describe a chronic and progressive clinical syndrome that affected adults living ... more about Tropical Spastic Paraparesis.

Tropical Spastic Paraparesis: A form of spastic partial paralysis of the lower limbs which occurs in the tropics. More detailed information about the symptoms, causes, and treatments of Tropical Spastic Paraparesis is available below.

Symptoms of Tropical Spastic Paraparesis

Treatments for Tropical Spastic Paraparesis

Home Diagnostic Testing

Home medical testing related to Tropical Spastic Paraparesis:

Wrongly Diagnosed with Tropical Spastic Paraparesis?

Tropical Spastic Paraparesis: Related Patient Stories

Tropical Spastic Paraparesis: Deaths

Read more about Deaths and Tropical Spastic Paraparesis.

Types of Tropical Spastic Paraparesis

  • HTLV-1 associated myelopathy/tropical spastic paraparesis(HAM/TSP)
  • Idiopathic TSP
  • more types...»

Tropical Spastic Paraparesis: Complications

Read more about complications of Tropical Spastic Paraparesis.

Causes of Tropical Spastic Paraparesis

More information about causes of Tropical Spastic Paraparesis:

Disease Topics Related To Tropical Spastic Paraparesis

Research the causes of these diseases that are similar to, or related to, Tropical Spastic Paraparesis:

Tropical Spastic Paraparesis: Undiagnosed Conditions

Commonly undiagnosed diseases in related medical categories:

Misdiagnosis and Tropical Spastic Paraparesis

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Tropical Spastic Paraparesis: Research Doctors & Specialists

Research related physicians and medical specialists:

Other doctor, physician and specialist research services:

Hospitals & Clinics: Tropical Spastic Paraparesis

Research quality ratings and patient safety measures for medical facilities in specialties related to Tropical Spastic Paraparesis:

Choosing the Best Hospital: More general information, not necessarily in relation to Tropical Spastic Paraparesis, on hospital performance and surgical care quality:

Evidence Based Medicine Research for Tropical Spastic Paraparesis

Medical research articles related to Tropical Spastic Paraparesis include:

Click here to find more evidence-based articles on the TRIP Database

Tropical Spastic Paraparesis: Animations

Prognosis for Tropical Spastic Paraparesis

Prognosis for Tropical Spastic Paraparesis: HAM/TSP is usually a progressive neurological disorder but it is rarely fatal. Most patients live for several decades after the diagnosis. Their prognosis improves if they take steps to prevent urinary tract infection and skin sore formation, and if they enroll in physical and occupational therapy programs. (Source: excerpt from NINDS Tropical Spastic Paraparesis Information Page: NINDS)

Research about Tropical Spastic Paraparesis

Visit our research pages for current research about Tropical Spastic Paraparesis treatments.

Clinical Trials for Tropical Spastic Paraparesis

The US based website ClinicalTrials.gov lists information on both federally and privately supported clinical trials using human volunteers.

Some of the clinical trials listed on ClinicalTrials.gov for Tropical Spastic Paraparesis include:

Statistics for Tropical Spastic Paraparesis

Tropical Spastic Paraparesis: Broader Related Topics

Tropical Spastic Paraparesis Message Boards

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User Interactive Forums

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Article Excerpts about Tropical Spastic Paraparesis

For several decades the term “tropical spastic paraparesis” (TSP) was used to describe a chronic and progressive clinical syndrome that affected adults living in equatorial areas of the world. This condition was initially thought to be associated with infectious agents (such as Treponema pertenue and Treponema pallidum which cause inflammation of the central nervous system) and with chronic nutritional deficiencies (such as avitaminosis) or exposure to potentially toxic foods (such as bitter cassava). Neurological and modern neuroepidemiological studies found that in some individuals no one cause could explain the progressive weakness, sensory disturbance, and sphincter dysfunction that affected individuals with TSP. In spite of public health programs created to eradicate the above-mentioned infectious and nutritional conditions in the tropics, large numbers of people continued to be affected. During the mid-1980's, an important association was established between the first human retrovirus-human T-cell lymphotrophic virus type 1 (also known as HTLV-1)-and idiopathic TSP (idiopathic means of unknown origin). Since then, this condition has been named HTLV-1 associated myelopathy/ tropical spastic paraparesis or HAM/TSP and scientists now understand that it is a condition caused by a virus that results in immune dysfunction. (Source: excerpt from NINDS Tropical Spastic Paraparesis Information Page: NINDS)

Definitions of Tropical Spastic Paraparesis:

A subacute paralytic myeloneuropathy occurring endemically in tropical areas such as the Caribbean, Colombia, India, and Africa, as well as in the southwestern region of Japan; associated with infection by human T-cell leukemia virus type I (HUMAN T-LYMPHOTROPIC VIRUS 1). Clinical manifestations include a slowly progressive spastic weakness of the legs, increased reflexes, Babinski signs, incontinence, and loss of vibratory and position sensation. On pathologic examination inflammatory, demyelination, and necrotic lesions may be found in the spinal cord. (Adams et al., Principles of Neurology, 6th ed, p1239) - (Source - Diseases Database)

Tropical Spastic Paraparesis is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH). This means that Tropical Spastic Paraparesis, or a subtype of Tropical Spastic Paraparesis, affects less than 200,000 people in the US population.
Source - National Institutes of Health (NIH)

 

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