Vaccinia necrosum: Vaccinia necrosum is a serious complication of smallpox vaccination. The condition involves progressive death of tissue (necrosis) at the site of the vaccination. The condition is relatively rare but can result in death so prompt diagnosis and treatment is essential. People with AIDS, immunodeficiencies, cancer, receiving immunosuppressive therapies or have some other form of immune system defect are particularly susceptible to this complication. More detailed information about the symptoms, causes, and treatments of Vaccinia necrosum is available below.
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