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A malignant tumor of the kidney that occurs predominantly in children less than 5 years old. It is the most common kidney cancer in children. Wilms' tumor usually only occurs in one kidney. Roughly 500 new cases are diagnosed in the US each year with about 6% of them involving both kidneys. Certain genetic syndromes may predispose children to Wilms' tumors e.g. Denys-Drash syndrome and Beckwith-Wiedemann syndrome. Also called nephroblastoma. ...more »
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The US based website ClinicalTrials.gov lists information on both federally and privately supported clinical trials using human volunteers.
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An embryonal pediatric tumor of the kidney which may also be seen rarely in adults. The peak incidence of Wilms tumor is between the second and fifth year of life. Microscopically, it is composed of a mixture of cellular elements (blastemal, stromal, and epithelial). The most common sites of metastasis include the regional lymph nodes, lungs, and liver. -- 2004 - (Source - Diseases Database)
Malignant renal tumor of young children characterized by hypertension and blood in the urine and the presence of a palpable mass - (Source - WordNet 2.1)
Wilms' tumor is listed as a "rare disease" by the Office of
Rare Diseases (ORD) of the National Institutes of Health
(NIH). This means that Wilms' tumor, or a subtype of Wilms' tumor,
affects less than 200,000 people in the US population.
Source - National Institutes of Health (NIH)
Ophanet, a consortium of European partners,
currently defines a condition rare when it affects 1 person per 2,000.
They list Wilms' tumor as a "rare disease".
Source - Orphanet
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