Zollinger-Ellison syndrome: Zollinger-Ellison syndrome is a rare disorder that causes tumors in the pancreas and duodenum and ulcers in the stomach and duodenum. ... more about Zollinger-Ellison syndrome.
Zollinger-Ellison syndrome: A rare disorder where excessive levels of the hormone gastrin are released into the stomach which increases stomach acidity which results in peptic ulcer development. A hormone secreting pancreatic or duodenal tumor is usually the cause. More detailed information about the symptoms, causes, and treatments of Zollinger-Ellison syndrome is available below.
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Zollinger-Ellison syndrome is a rare disorder that causes tumors in the pancreas and duodenum and ulcers in the stomach and duodenum. The pancreas is a gland located behind the stomach. It produces enzymes that break down fat, protein, and carbohydrates from food, and hormones like insulin that break down sugar. The duodenum is the top part of the small intestine.
The tumors are cancerous in 50 percent of cases. They secrete a substance called gastrin that causes the stomach to produce too much acid, which in turn causes the stomach and duodenal ulcers (peptic ulcers). The ulcers caused by Zollinger-Ellison syndrome are more painful and less responsive to treatment than ordinary peptic ulcers. (Source: excerpt from Zollinger-Ellison Syndrome: NIDDK)
A gastrin-secreting tumor of the non-beta islet cells. It is usually located in the pancreas but is also found at other sites, as in the antrum of the stomach, hilus of the spleen, and regional lymph nodes. The presence of gastrinoma is one of three requirements to be met for identification of ZOLLINGER-ELLISON SYNDROME, which sometimes occurs in families with MULTIPLE ENDOCRINE NEOPLASIA TYPE 1 (MEN-1). Gastrinomas in patients with MEN-1 are usually diffuse in nature. - (Source - Diseases Database)
Syndrome consisting of intractable peptic ulceration with gastric hypersecretion and hyperacidity - (Source - WordNet 2.1)
Zollinger-Ellison syndrome is listed as a "rare disease" by the Office of
Rare Diseases (ORD) of the National Institutes of Health
(NIH). This means that Zollinger-Ellison syndrome, or a subtype of Zollinger-Ellison syndrome,
affects less than 200,000 people in the US population.
Source - National Institutes of Health (NIH)
Ophanet, a consortium of European partners,
currently defines a condition rare when it affects 1 person per 2,000.
They list Zollinger-Ellison syndrome as a "rare disease".
Source - Orphanet
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