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What is Adrenoleukodystrophy?

What is Adrenoleukodystrophy?

  • Adrenoleukodystrophy: A rare disorder which has characteristic symptoms of Addison disease (adrenocortical insufficiency) and Schilder disease (cerebral sclerosis). Bronze skin, brain sclerosis and demyelination are the main symptoms.
  • Adrenoleukodystrophy: A syndrome combining the characteristics of adrenocortical insufficiency (Addison disease) with those of cerebral sclerosis (Schilder disease). Skin bronzing and sclerosis of the brain and demyelination are the principal manifestations.
    Source - Diseases Database

Adrenoleukodystrophy is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH). This means that Adrenoleukodystrophy, or a subtype of Adrenoleukodystrophy, affects less than 200,000 people in the US population.
Source - National Institutes of Health (NIH)

Adrenoleukodystrophy: Introduction

Types of Adrenoleukodystrophy:

Types of Adrenoleukodystrophy:

Broader types of Adrenoleukodystrophy:

How many people get Adrenoleukodystrophy?

Prevalance of Adrenoleukodystrophy: 1 per 20,000 people suffer from X-linked adrenoleukodystrophy, Genetics Home reference website
Prevalance Rate of Adrenoleukodystrophy: approx 1 in 20,000 or 0.00% or 13,600 people in USA [about data]

How serious is Adrenoleukodystrophy?

Complications of Adrenoleukodystrophy: see complications of Adrenoleukodystrophy
Prognosis of Adrenoleukodystrophy: Prognosis for patients with ALD is generally poor except after successful bone marrow transplantation. Death may occur within 1 to 10 years after the onset of symptoms due to disease progression. (Source: excerpt from NINDS Adrenoleukodystrophy Information Page: NINDS)

What causes Adrenoleukodystrophy?

Causes of Adrenoleukodystrophy: see causes of Adrenoleukodystrophy

What are the symptoms of Adrenoleukodystrophy?

Symptoms of Adrenoleukodystrophy: see symptoms of Adrenoleukodystrophy

Complications of Adrenoleukodystrophy: see complications of Adrenoleukodystrophy

Can anyone else get Adrenoleukodystrophy?

Contagion of genetic conditions: generally not; see details in contagion of genetic diseases.

Inheritance of genetic conditions: see details in inheritance of genetic diseases.

Adrenoleukodystrophy: Testing

Diagnostic testing: see tests for Adrenoleukodystrophy.

Misdiagnosis: see misdiagnosis and Adrenoleukodystrophy.

How is it treated?

Treatments for Adrenoleukodystrophy: see treatments for Adrenoleukodystrophy
Research for Adrenoleukodystrophy: see research for Adrenoleukodystrophy

Organs Affected by Adrenoleukodystrophy:

Organs and body systems related to Adrenoleukodystrophy include:

Name and Aliases of Adrenoleukodystrophy

Main name of condition: Adrenoleukodystrophy

Class of Condition for Adrenoleukodystrophy: genetic

Other names or spellings for Adrenoleukodystrophy:

Addison-Schilder disease, ALD, Simerling-Creutzfeldt, Addison-Scholz, Addison-Schilder, bronze syndrome, melanodermic leukodystrophy, sudanophilic leukodystrophy [bronzing of skin - adrenal atrophy], Addison disease [spastic paraplegia syndrome], Fanconi-Prader syndrome, Siemerling-Creutzfeldt syndrome, adrenocortical atrophy [cerebral sclerosis syndrome], bronze Schilder disease, Addison disease with cerebral sclerosis, encephalitis periaxialis diffusa, Flatau-Schilder disease, Myelinoclastic diffuse sclerosis, X-linked adrenoleukodystrophy, AMN, Adrenomyeloneuropathy, Siemerling-Creutzfeldt disease, Addison disease and cerebral sclerosis

Adrenomyeloneuropathy, Bronze Schilder disease, Siemerling-Creutzfeldt disease, Adrenoleucodystrophy, Addison-Schilder syndrome Source - Diseases Database

AMN, Addison disease and cerebral sclerosis, Addison-Schilder syndrome, Adrenomyeloneuropathy, Bronze Schilder disease, Schilder's disease, Siemerling-Creutzfeldt disease, Adrenomyeloneuropathy, Bronze Schilder disease, Schilder's disease, Siemerling-Creutzfeldt disease, AMN, Addison disease and cerebral sclerosis, X-linked adrenoleukodystrophy, Adrenoleukodystrophy, X-linked
Source - Office of Rare Diseases (ORD) of the National Institutes of Health (NIH)

Adrenoleukodystrophy: Related Conditions

Research the causes of these diseases that are similar to, or related to, Adrenoleukodystrophy:


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