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Alexander Syndrome

Alexander Syndrome: Introduction

Alexander Syndrome: Alexander disease is a rare, genetic, degenerative disorder of the nervous system. It is one of a group of genetic disorders called the ... more about Alexander Syndrome.

Alexander Syndrome: Brain myelin disorder causing mental degeneration. More detailed information about the symptoms, causes, and treatments of Alexander Syndrome is available below.

Symptoms of Alexander Syndrome

Treatments for Alexander Syndrome

Home Diagnostic Testing

Home medical testing related to Alexander Syndrome:

Wrongly Diagnosed with Alexander Syndrome?

Alexander Syndrome: Related Patient Stories

Types of Alexander Syndrome

  • Infantile Alexander Syndrome - most common form
  • Juvenile Alexander Syndrome
  • Adult-onset Alexander Syndrome
  • more types...»

Alexander Syndrome: Complications

Review possible medical complications related to Alexander Syndrome:

Causes of Alexander Syndrome

Read more about causes of Alexander Syndrome.

Alexander Syndrome: Undiagnosed Conditions

Commonly undiagnosed diseases in related medical categories:

Misdiagnosis and Alexander Syndrome

Mild worm infections undiagnosed in children: Human worm infestations, esp. threadworm, can be overlooked in some cases, because it may cause only mild or even absent symptoms. Although the most common more »

Undiagnosed stroke leads to misdiagnosed aphasia: BBC News UK reported on a man who had been institutionalized and treated for mental illness because he suffered from more »

Dementia may be a drug interaction: A common scenario in aged care is for a patient to show mental decline to dementia. Whereas this can, of course, occur due to various medical conditions, such as a stroke or Alzheimer's disease, more »

Mesenteric adenitis misdiagnosed as appendicitis in children: Because appendicitis is one of the more feared conditions for a child with abdominal pain, it can be over-diagnosed (it can, of course, also fail to be diagnosed with fatal more »

Blood pressure cuffs misdiagnose hypertension in children: One known misdiagnosis issue with hyperension, arises in relation to the simple equipment used to test blood pressure. The more »

Mild traumatic brain injury often remains undiagnosed: Although the symptoms of severe brain injury are hard to miss, it is less clear for milder injuries, or even those causing a mild more »

MTBI misdiagnosed as balance problem: When a person has symptoms such as vertigo or dizziness, a diagnosis of brain injury may go overlooked. This is particularly true of more »

Brain pressure condition often misdiagnosed as dementia: A condition that results from an excessive pressure of CSF within the brain is more »

Post-concussive brain injury often misdiagnosed: A study found that soldiers who had suffered a concussive injury in battle often were misdiagnosed on their return. A variety of symptoms more »

Children with migraine often misdiagnosed: A migraine often fails to be correctly diagnosed in pediatric patients. These patients are not the typical more »

Vitamin B12 deficiency under-diagnosed: The condition of Vitamin B12 deficiency is a possible misdiagnosis of various conditions, such as multiple sclerosis (see symptoms of multiple sclerosis). See symptoms more »

Alexander Syndrome: Research Doctors & Specialists

Research related physicians and medical specialists:

Other doctor, physician and specialist research services:

Hospitals & Clinics: Alexander Syndrome

Research quality ratings and patient safety measures for medical facilities in specialties related to Alexander Syndrome:

Choosing the Best Hospital: More general information, not necessarily in relation to Alexander Syndrome, on hospital performance and surgical care quality:

Alexander Syndrome: Rare Types

Rare types of diseases and disorders in related medical categories:

Alexander Syndrome: Animations

Prognosis for Alexander Syndrome

Prognosis for Alexander Syndrome: Poor. Life-shortening. Children often die before 6 years.

Statistics for Alexander Syndrome

Alexander Syndrome: Broader Related Topics

Alexander Syndrome Message Boards

Related forums and medical stories:

User Interactive Forums

Read about other experiences, ask a question about Alexander Syndrome, or answer someone else's question, on our message boards:

Article Excerpts about Alexander Syndrome

Alexander disease is a rare, genetic, degenerative disorder of the nervous system. It is one of a group of genetic disorders called the leukodystrophies that affect growth of the myelin sheath the fatty covering which acts as an insulator on nerve fibers in the brain. (Source: excerpt from NINDS Alexander Disease Information Page: NINDS)

Definitions of Alexander Syndrome:

A rare inherited disorder of myelin formation. Alexander disease is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of cytoplasmic inclusions called Rosenthal fibers. The fibers contain GLIAL FIBRILLARY ACIDIC PROTEIN in association with ALPHA-CRYSTALLIN B CHAIN. Rosenthal fibers are found predominantly in ASTROCYTES located in the subependymal, subpial, and periventricular areas of the BRAIN. - (Source - Diseases Database)

Alexander Syndrome is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH). This means that Alexander Syndrome, or a subtype of Alexander Syndrome, affects less than 200,000 people in the US population.
Source - National Institutes of Health (NIH)

Ophanet, a consortium of European partners, currently defines a condition rare when it affects 1 person per 2,000. They list Alexander Syndrome as a "rare disease".
Source - Orphanet


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