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Diseases » Angelman syndrome » Summary

What is Angelman syndrome?

What is Angelman syndrome?

Prader-Willi syndrome and Angelman syndrome are two rare chromosome disorders, with very different symptoms, but caused by the same area of DNA. ...more »

  • Angelman syndrome: A rare genetic disorder characterized by a puppet-like gait, fits of laughter and characteristic facial features.
  • Angelman syndrome: A condition in which children laugh frequently for almost any reason and whose jerky movements and flapping of the hands are similar to those of a marionette, or puppet-- hence the synonym "happy puppet syndrome." Other disorders include a peculiar facial expression, mental retardation, movement disorders, microbrachycephaly, and various neurological disorders.
    Source - Diseases Database

Angelman syndrome is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH). This means that Angelman syndrome, or a subtype of Angelman syndrome, affects less than 200,000 people in the US population.
Source - National Institutes of Health (NIH)

Ophanet, a consortium of European partners, currently defines a condition rare when it affects 1 person per 2,000. They list Angelman syndrome as a "rare disease".
Source - Orphanet

Angelman syndrome: Introduction

Types of Angelman syndrome:

Broader types of Angelman syndrome:

How many people get Angelman syndrome?

Prevalance of Angelman syndrome: 1 per 12,000 - 20,000 people are affected by Angelman syndrome, Genetics Home Reference website
Prevalance Rate of Angelman syndrome: approx 1 in 12,000 or 0.01% or 22,666 people in USA [about data]

How serious is Angelman syndrome?

Prognosis of Angelman syndrome: Good survival rate but with mental delay or retardation, and physical problems such as balance and speech abnormalities.
Complications of Angelman syndrome: see complications of Angelman syndrome
Prognosis of Angelman syndrome: Most individuals with Angelman syndrome will have mental delay, severe speech limitations, and some type of gait abnormality. Patients may have improvement of symptoms with therapy. (Source: excerpt from NINDS Angelman Syndrome Information Page: NINDS)

What causes Angelman syndrome?

Causes of Angelman syndrome: see causes of Angelman syndrome

What are the symptoms of Angelman syndrome?

Symptoms of Angelman syndrome: see symptoms of Angelman syndrome

Complications of Angelman syndrome: see complications of Angelman syndrome

Can anyone else get Angelman syndrome?

Inheritance: see inheritance of Angelman syndrome

Inheritance of genetic conditions: see details in inheritance of genetic diseases.

Angelman syndrome: Testing

Diagnostic testing: see tests for Angelman syndrome.

Misdiagnosis: see misdiagnosis and Angelman syndrome.

How is it treated?

Doctors and Medical Specialists for Angelman syndrome: Medical Geneticist ; see also doctors and medical specialists for Angelman syndrome.
Treatments for Angelman syndrome: see treatments for Angelman syndrome
Research for Angelman syndrome: see research for Angelman syndrome

Organs Affected by Angelman syndrome:

Organs and body systems related to Angelman syndrome include:

Name and Aliases of Angelman syndrome

Main name of condition: Angelman syndrome

Class of Condition for Angelman syndrome: genetic chromosomal

Other names or spellings for Angelman syndrome:

Happy puppet syndrome, AS, Happy puppet syndrome (formerly)

Happy puppet syndrome Source - Diseases Database

AS, HPS(Happy puppet syndrome), Happy puppet syndrome, Puppet children, Puppetlike syndrome, Puppet children, Puppetlike syndrome, AS, HPS(Happy puppet syndrome)
Source - Office of Rare Diseases (ORD) of the National Institutes of Health (NIH)

Angelman syndrome: Related Conditions

Research the causes of these diseases that are similar to, or related to, Angelman syndrome:


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