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Diseases » Ataxia Telangiectasia » Inheritance

Inheritance and Genetics of Ataxia Telangiectasia

Ataxia Telangiectasia: Genetics Information

Genetics of Ataxia Telangiectasia: Back in 1988 the gene responsible for A-T was mapped to chromosome 11. The subsequent identification of the gene proved difficult; it was 7 more years until the human ATM gene was cloned. The diverse symptoms seen in A-T reflect the main role of ATM, which is to induce several cellular responses to DNA damage. When the ATM gene is mutated, these signaling networks are impaired, and so the cell does not respond correctly to minimize the damage. (Source: Genes and Disease by the National Center for Biotechnology)

About inheritance and genetics:

Inheritance of Ataxia Telangiectasia refers to whether the condition is inherited from your parents or "runs" in families. The level of inheritance of a condition depends on how important genetics are to the disease. Strongly genetic diseases are usually inherited, partially genetic diseases are sometimes inherited, and non-genetic diseases are not inherited. For general information, see Introduction to Genetics.


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