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Articles » NINDS Vasculitis including Temporal Arteritis Information Page: NINDS

NINDS Vasculitis including Temporal Arteritis Information Page: NINDS

Article title: NINDS Vasculitis including Temporal Arteritis Information Page: NINDS

Main condition: Vasculitis

Conditions: Vasculitis, Temporal arteritis

Table of Contents (click to jump to sections)What is Vasculitis including Temporal Arteritis?
Is there any treatment?
What is the prognosis?
What research is being done?

Selected references

What is Vasculitis including Temporal Arteritis?
Vasculitis is an inflammation of the blood vessel system, which includes the veins, arteries, and capillaries. Vasculitis may affect blood vessels of any type, size, or location, and therefore can cause dysfunction in any organ system, including the central and peripheral nervous systems. The symptoms of vasculitis depend on which blood vessels are involved and what organs in the body are affected. The disorder may occur alone or with other disorders such as temporal arteritis. Temporal arteritis (also called cranial or giant cell arteritis) is an inflammation of the temporal artery (which runs over the temple, beside the eye). Symptoms of this disorder may include stiffness, muscle pain, fever, severe headaches, pain when chewing, and tenderness in the temple area. Other symptoms may include anemia, fatigue, weight loss, shaking, vision loss, and sweats.

Is there any treatment?
Treatment for vasculitis depends on the severity of the disorder and the individual's general health. Treatment may include cortisone or cytotoxic drugs. Other treatments may include plasmapheresis (the removal and reinfusion of blood plasma), intravenous gammaglobulin, and cyclosporin. Some cases of vasculitis may not require treatment. Treatment for temporal arteritis and its associated symptoms generally includes corticosteroid therapy. Early detection of temporal arteritis and immediate treatment are essential to prevent vision loss.

What is the prognosis?
The prognosis for individuals with vasculitis varies depending on the severity of the disorder. Mild cases of vasculitis are generally not life-threatening, while severe cases (involving major organ systems) may be permanently disabling or fatal. The prognosis for individuals with temporal arteritis is generally good. With treatment, most individuals achieve complete remission, however vision loss may be irreversible.

What research is being done?
Several components of the NIH support research on vasculitis and temporal arteritis. The ultimate goals of this research are to increase scientific understanding of these disorders and to find ways to prevent, treat, and cure them.

Selected references

Fauci, A.
The Vasculitis Syndromes In Harrison?s Principles of Internal Medicine, Vol. 2, 13th edition, McGraw-Hill Book Co., New York, pp. 1670-1679 (1994)

Gatenby, PA.
Vasculitis-Diagnosis and Treatment Australian and New Zealand Journal of Medicine 29(5); 662-677 (1999)

Lee, AG, and Brazis, PW.
Temporal Arteritis: A Clinical Approach Journal of the American Geriatric Society 47(11); 1364-1370 (1999)

Moore, PM.
Central Nervous System Vasculitis Current Opinions in Neurology 11(3); 241-246 (1998)

Beers, MH, and Berkow, R (eds).
The Merck Manual of Diagnosis and Therapy 17th edition, Merck Research Laboratories, Whitehouse Station, NJ, p. 437-439 (1999)


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This fact sheet is in the public domain. You may copy it.Provided by:
The National Institute of Neurological Disorders and Stroke
National Institutes of Health
Bethesda, MD 20892

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