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Articles » West African Trypanosomiasis: DPD

West African Trypanosomiasis: DPD

Article title: West African Trypanosomiasis: DPD

Conditions: West African Trypanosomiasis, African trypanosomiasis

Source: DPD


West African Trypanosomiasis


What is African trypanosomiasis?

There are two types of African trypanosomiasis, also called sleeping sickness, named for the areas in Africa in which they are found. West African trypanosomiasis, also called Gambian sleeping sickness, is caused by a parasite called Trypanosoma brucei gambiense (tri-PAN-o-SO-ma brew-see-eye gam-be-ense). Worldwide, 20,000 new cases of both East and West African trypanosomiasis are reported each year. Few cases of West African trypanosomiasis have been reported in the United States.

How can I get West African trypanosomiasis?

  • Through the bite of an infected tsetse fly, found only in Africa.


  • If you are infected and pregnant, you may pass infection to your baby.
  • Through blood transfusion or by organ transplant.

Is West African trypanosomiasis a serious illness?

Yes. If left untreated, death will occur.

What are the symptoms of West African trypanosomiasis?

A bite by the tsetse fly is often painful. Occasionally, 1-2 weeks after the tsetse fly bite, a red sore, also called a chancre (SHAN-ker) appears at the site of the infective bite. Several weeks to months later, other symptoms of sleeping sickness occur. These include fever, rash, swelling around the eye and hands, severe headaches, extreme fatigue, aching muscles and joints. You may develop swollen lymph nodes on the back of your neck called Winterbottom's sign. Weight loss occurs as the illness progresses. Personality changes, irritability, loss of concentration, progressive confusion, slurred speech, seizures, and difficulty in walking and talking occurs when infection has invaded the central nervous system. These symptoms become worse as illness progresses. Sleeping for long periods of the day and having insomnia at night is a common symptom. If left untreated, infection becomes worse and death will occur within several months to years after infection.

How soon after infection will I have symptoms of West African trypanosomiasis?

Symptoms occur within months to years after infection.

Can I take medication to prevent West African trypanosomiasis?

There is neither a vaccine nor recommended drug available to prevent West African trypanosomiasis.

What should I do if I think I have African trypanosomiasis?

See your health care provider who will order several tests to look for the parasite. Common tests include blood samples and a spinal tap. Your physician may also take a sample of fluid from swollen lymph nodes.

What is the treatment for West African trypanosomiasis?

Treatment should be started as soon as possible and is based on the infected personís symptoms and laboratory results. Medication for the treatment of West African trypanosomiasis is available. Hospitalization for treatment is necessary and periodic follow-up exams that include a spinal tap are required for 2 years.

Where can I contract West African trypanosomiasis?

West African trypanosomiasis can be contracted in parts of Western and Central Africa; see the map for areas where illness can be found. The tsetse fly lives only in Africa; areas where infection is spread are largely determined by where the infected tsetse fly is found.

Who is at risk for contracting West African trypanosomiasis?

Tsetse flies can be found in Western and Central African forests, in areas of thick shrubbery and trees by rivers and waterholes. Risk of infection increases with the number of times a person is bitten by the tsetse fly. Therefore, tourists are not at great risk for contracting West African trypanosomiasis unless they are traveling and spending long periods of time in rural areas of Western and Central Africa.

How can I prevent African trypanosomiasis and other insect bites?

  • Wear protective clothing, including long-sleeved shirts and pants. The tsetse fly can bite through thin fabrics, so clothing should be made of thick material.
  • Wear khaki or olive colored clothing. The tsetse fly is attracted to bright colors and very dark colors.
  • Use insect repellant. Though insect repellants have not proven effective in preventing tsetse fly bites, they are effective in preventing other insects from biting and causing illness.
  • When sleeping, use bednets.
  • Inspect vehicles for tsetse flies before entering.
  • Donít ride in the back of jeeps, pickup trucks or other open vehicles. The tsetse fly is attracted to the dust that moving vehicles and wild animals create.
  • Avoid bushes. The tsetse fly is less active during the hottest period of the day. It rests in bushes but will bite if disturbed.

For more information:

  1. Bryan R, Waskin J, Richards F, et al. African trypanosomiasis in American travelers: a 20-year review. Travel Medicine. Steffen R, Lobel HO, Haworth J, Bradley DJ, eds. Berlin: Springer-Verlag, 1989:384-8.
  2. McGovern TW, William W, Fitzpatrick JE, et al. Cutaneous manifestations of African trypanosomiasis. Arch Dermatol 1995;131:1178-82.


This fact sheet is for information only and is not meant to be used for self-diagnosis or as a substitute for consultation with a health care provider. If you have any questions about the disease described above or think that you may have a parasitic infection, consult a health care provider.



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