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Diseases » Bipolar disorder » Research

Cure Research for Bipolar disorder

Curable Types of Bipolar disorder

Possibly curable or rare types of Bipolar disorder include:

Rare Types of Bipolar disorder:

Some rare types of Bipolar disorder include:

Treatments for Bipolar disorder

Treatments to consider for Bipolar disorder may include:

Cure Research discussion for Bipolar disorder:

Going to Extremes Bipolar Disorder: NIMH (Excerpt)

NIMH has initiated a large-scale study at 20 sites across the U.S. to determine the most effective treatment strategies for people with bipolar disorder. This study, the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD), will follow patients and document their treatment outcome for 5 to 8 years. For more information, visit the Clinical Trials page of the NIMH Web site. (Source: excerpt from Going to Extremes Bipolar Disorder: NIMH)

Going to Extremes Bipolar Disorder: NIMH (Excerpt)

More than two-thirds of people with bipolar disorder have at least one close relative with the disorder or with unipolar major depression, indicating that the disease has a heritable component. 9 Studies seeking to identify the genetic basis of bipolar disorder indicate that susceptibility stems from multiple genes. Scientists are continuing their search for these genes using advanced genetic analytic methods and large samples of families affected by the illness. The researchers are hopeful that identification of susceptibility genes for bipolar disorder, and the brain proteins they code for, will make it possible to develop better treatments and preventive interventions targeted at the underlying illness process.

Researchers are using advanced imaging techniques to examine brain function and structure in people with bipolar disorder. 10 ,11 An important area of imaging research focuses on identifying and characterizing networks of interconnected nerve cells in the brain, interactions among which form the basis for normal and abnormal behaviors. Researchers hypothesize that abnormalities in the structure and/or function of certain brain circuits could underlie bipolar and other mood disorders. Better understanding of the neural circuits involved in regulating mood states will influence the development of new and better treatments, and will ultimately aid in diagnosis. (Source: excerpt from Going to Extremes Bipolar Disorder: NIMH)

Bipolar Disorder: NIMH (Excerpt)

Omega-3 fatty acids found in fish oil are being studied to determine their usefulness, alone and when added to conventional medications, for long-term treatment of bipolar disorder.23 (Source: excerpt from Bipolar Disorder: NIMH)

Bipolar Disorder Research at the National Institute of Mental Health: NIMH (Excerpt)

For patients who either do not respond to lithium or cannot tolerate its side effects, which can include weight gain, tremor, and excessive urination, there are several anticonvulsant medications that may serve as alternative mood stabilizers. Valproate and carbamazepine have been used for the past two decades for treatment of acute mania and prevention of cycling. However, valproate is the only anticonvulsant approved by the U.S. Food and Drug Administration (FDA) for use with bipolar disorder - specifically, for the acute treatment of mania. NIMH researchers are currently investigating the efficacy of newer anticonvulsant drugs, including lamotrigine and gabapentin, as mood stabilizers for treatment refractory bipolar disorder. (13)   Topiramate is also receiving attention in clinical studies. (Source: excerpt from Bipolar Disorder Research at the National Institute of Mental Health: NIMH)

Bipolar Disorder Research at the National Institute of Mental Health: NIMH (Excerpt)

NIMH researchers are conducting studies to evaluate the benefits of specific types of adjunctive psychotherapy in the long-term management of bipolar disorder. These psychotherapies include Psychoeducation (PE), Cognitive-Behavioral Therapy (CBT), Family Focused Therapy (FFT), and Interpersonal and Social Rhythm Therapy (IPSRT). PE involves teaching patients with bipolar disorder about their illness and its treatment. Emphasis is placed on recognizing early signs of relapse so that patients can seek medical care before a full-blown illness episode develops. CBT helps patients modify detrimental or inappropriate thought patterns and behaviors associated with bipolar disorder. FFT employs strategies to reduce the level of distress within the family that may either contribute to or result from the ill person's symptoms. IPSRT uses techniques aimed at regularizing daily routines and improving interpersonal relationships. Research indicates that regular daily routines and sleep schedules may protect against manic episodes. (19)   A large-scale NIMH study (called STEP-BD, described below) will compare the effectiveness of intensive CBT, FFT, and IPSRT, each in combination with medication, for treatment of acute depressive episodes and for prevention of recurrent episodes in people with bipolar disorder. (Source: excerpt from Bipolar Disorder Research at the National Institute of Mental Health: NIMH)

Bipolar Disorder Research at the National Institute of Mental Health: NIMH (Excerpt)

Based on the clinical observation that episodes are often precipitated by disruptions of sleep or other daily routines, a group of NIMH-funded researchers developed interpersonal and social rhythm therapy (IPSRT) to help stabilize the course of bipolar disorder. IPSRT teaches patients techniques to regularize their daily routines and improve their interpersonal relationships. In preliminary studies, IPSRT, in combination with ongoing medication maintenance, reduced depressive symptoms and improved the quality of remission from active bipolar disorder. (21)   Patients who received IPSRT as a preventive intervention spent more time in a balanced state and less time in a subclinical depressive condition. (Source: excerpt from Bipolar Disorder Research at the National Institute of Mental Health: NIMH)

Medical research for Bipolar disorder: medical news summaries:

The following medical news items are relevant to medical research for Bipolar disorder:

Clinical Trials for Bipolar disorder

Some of the clinical trials for Bipolar disorder include:

Evidence Based Medicine Research for Bipolar disorder

Medical research papers related to Bipolar disorder include:

Click here to find more evidence-based articles on the TRIP Database


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