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Diseases » Chronic myeloid leukemia » Inheritance

Inheritance and Genetics of Chronic myeloid leukemia

Genetics of Chronic myeloid leukemia:

Chronic myeloid leukemia is not inherited or passed down to subsequent generations.

Chronic myeloid leukemia: Genetics Information

Genetics of Chronic myeloid leukemia: The Ph chromosome is the result of a translocation --- or exchange of genetic material --- between the long arms of chromosomes 9 and 22 . This exchange brings together two genes: the BCR (breakpoint cluster region) gene on chromosome 22 and the proto-oncogene ABL (Ableson leukemia virus) on chromosome 9. The resulting hybrid gene BCR-ABL codes for a fusion protein with tyrosine kinase activity, which activates signal transduction pathways, leading to uncontrolled cell growth. (Source: Genes and Disease by the National Center for Biotechnology)

About inheritance and genetics:

Inheritance of Chronic myeloid leukemia refers to whether the condition is inherited from your parents or "runs" in families. The level of inheritance of a condition depends on how important genetics are to the disease. Strongly genetic diseases are usually inherited, partially genetic diseases are sometimes inherited, and non-genetic diseases are not inherited. For general information, see Introduction to Genetics.


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