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Pseudomyxoma peritonei is a locally malignant unusual disease commonly seen in females which is caused by a low -grade mucinous cystadenocarcinoma of the appendix or ovary that secretes large amounts of mucus containing epithelial cells. In most cases the site of origin is the appendix with secondary implantation in one or both the ovaries. In this condition there is diffuse collection of gelatinous fluid in the peritoneal cavity associated with mucinous implants on the surface of the peritoneum and omentum.There is no lymph node or extraperitoneal metastasis.
Psudomyxoma is often asymptomatic until very late in its course with the patient often experiencing overall deterioration of health long before the diagnosis is made. The symptoms are non specific and include abdominal pain and abdominal distention. Occasionally a palpable mass may be present. It is usually confused with loculated ascites and ovarian carcinoma. It can be investigated using US and CT scan. The treatment consists of thorough surgical debulking along with adjuvant intraperitoneal chemotherapy. Appendicectomy is routinely performed along with Bilateral salpingo-oopherectomy in females.
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