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Diseases » Friedreich's ataxia » Inheritance
 

Inheritance and Genetics of Friedreich's ataxia

Friedreich's ataxia: Genetics Information

Genetics of Friedreich's ataxia: FRDA is an autosomal recessive disease caused by a mutation of a gene called frataxin, which is located on chromosome 9. This mutation means that there are many extra copies of a DNA segment, the trinucleotide GAA. A normal individual has 8 to 30 copies of this trinucleotide, while FRDA patients have as many as 1000. The larger the number of GAA copies, the earlier the onset of the disease and the quicker the decline of the patient. (Source: Genes and Disease by the National Center for Biotechnology)

About inheritance and genetics:

Inheritance of Friedreich's ataxia refers to whether the condition is inherited from your parents or "runs" in families. The level of inheritance of a condition depends on how important genetics are to the disease. Strongly genetic diseases are usually inherited, partially genetic diseases are sometimes inherited, and non-genetic diseases are not inherited. For general information, see Introduction to Genetics.

 

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