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Diseases » Friedreich's ataxia » Research
 

Cure Research for Friedreich's ataxia

Treatments for Friedreich's ataxia

Treatments to consider for Friedreich's ataxia may include:

Cure Research discussion for Friedreich's ataxia:

Genes and Disease by the National Center for Biotechnology (Excerpt)

Although we know that frataxin is found in the mitochondria of humans, we do not yet know its function. However, there is a very similar protein in yeast, YFH1, which we know more about. YFH1 is involved in controlling iron levels and respiratory function. Since frataxin and YFH1 are so similar, studying YFH1 may help us understand the role of frataxin in FRDA. (Source: Genes and Disease by the National Center for Biotechnology)

NINDS Friedreich's Ataxia Information Page: NINDS (Excerpt)

Studies have revealed that frataxin, a protein that should normally be present in the nervous system, the heart, and the pancreas, is severely reduced in patients with Friedreich's ataxia. Studies have shown that patients have abnormally high levels of iron in their heart tissue. It is believed that the nervous system, heart, and pancreas may be particularly susceptible to damage from free radicals (produced when the excess iron reacts with oxygen) because once certain cells in these tissues are destroyed by free radicals they cannot be replaced. Nerve and muscle cells also have metabolic needs that may make them particularly vulnerable to free radical damage. The discovery of the genetic mutation that causes Friedreich's ataxia has added new impetus to research efforts on this disease. (Source: excerpt from NINDS Friedreich's Ataxia Information Page: NINDS)

Evidence Based Medicine Research for Friedreich's ataxia

Medical research papers related to Friedreich's ataxia include:

Click here to find more evidence-based articles on the TRIP Database

 

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