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Holoprosencephaly: Introduction

Holoprosencephaly: Holoprosencephaly is a disorder caused by the failure of the prosencephalon (the forebrain of the embryo) to divide to form bilateral cerebral ... more about Holoprosencephaly.

Holoprosencephaly: A rare disorder where abnormalities of the fetal forebrain development lead to various birth defects. More detailed information about the symptoms, causes, and treatments of Holoprosencephaly is available below.

Symptoms of Holoprosencephaly

Treatments for Holoprosencephaly

Home Diagnostic Testing

Home medical testing related to Holoprosencephaly:

Wrongly Diagnosed with Holoprosencephaly?

Holoprosencephaly: Related Patient Stories

Holoprosencephaly: Deaths

Read more about Deaths and Holoprosencephaly.

Types of Holoprosencephaly

  • Alobar Holoprosencephaly
  • Semilobar Holoprosencephaly
  • Lobar Holoprosencephaly
  • more types...»

Holoprosencephaly: Complications

Read more about complications of Holoprosencephaly.

Causes of Holoprosencephaly

Read more about causes of Holoprosencephaly.

More information about causes of Holoprosencephaly:

Disease Topics Related To Holoprosencephaly

Research the causes of these diseases that are similar to, or related to, Holoprosencephaly:

Holoprosencephaly: Undiagnosed Conditions

Commonly undiagnosed diseases in related medical categories:

Misdiagnosis and Holoprosencephaly

Undiagnosed stroke leads to misdiagnosed aphasia: BBC News UK reported on a man who had been institutionalized and treated for mental illness because he suffered from sudden inability to speak. This was more »

Dementia may be a drug interaction: A common scenario in aged care is for a patient to show mental decline to dementia. Whereas this can, of course, occur due to various medical conditions, such as a stroke or Alzheimer's more »

Mild traumatic brain injury often remains undiagnosed: Although the symptoms of severe brain injury are hard to miss, it is less clear for milder injuries, or even those causing more »

MTBI misdiagnosed as balance problem: When a person has symptoms such as vertigo or dizziness, a diagnosis of brain injury may go overlooked. This is particularly true of more »

Brain pressure condition often misdiagnosed as dementia: A condition that results from an excessive pressure of CSF within the brain is often misdiagnosed. It may be misdiagnosed as more »

Post-concussive brain injury often misdiagnosed: A study found that soldiers who had suffered a concussive injury in battle often were misdiagnosed on their return. A variety of symptoms can occur in post-concussion syndrome more »

Children with migraine often misdiagnosed: A migraine often fails to be correctly diagnosed in pediatric patients. These patients are not the typical migraine sufferers, but migraines can also occur in children. See misdiagnosis of more »

Vitamin B12 deficiency under-diagnosed: The condition of Vitamin B12 deficiency is a possible misdiagnosis of various conditions, such as multiple sclerosis (see symptoms more »

Holoprosencephaly: Research Doctors & Specialists

Research related physicians and medical specialists:

Other doctor, physician and specialist research services:

Holoprosencephaly: Rare Types

Rare types of diseases and disorders in related medical categories:

Holoprosencephaly: Animations

Prognosis for Holoprosencephaly

Prognosis for Holoprosencephaly: The prognosis for individuals with the disorder is poor. Most of those who survive show no significant developmental gains. (Source: excerpt from NINDS Holoprosencephaly Information Page: NINDS)

Research about Holoprosencephaly

Visit our research pages for current research about Holoprosencephaly treatments.

Clinical Trials for Holoprosencephaly

The US based website lists information on both federally and privately supported clinical trials using human volunteers.

Some of the clinical trials listed on for Holoprosencephaly include:

Statistics for Holoprosencephaly

Holoprosencephaly: Broader Related Topics

Holoprosencephaly Message Boards

Related forums and medical stories:

User Interactive Forums

Read about other experiences, ask a question about Holoprosencephaly, or answer someone else's question, on our message boards:

Article Excerpts about Holoprosencephaly

Holoprosencephaly is a disorder caused by the failure of the prosencephalon (the forebrain of the embryo) to divide to form bilateral cerebral hemispheres, causing defects in the development of the face and in brain structure and function. Once called arhinencephaly, the disorder consists of a spectrum of defects or malformations of the brain and face. (Source: excerpt from NINDS Holoprosencephaly Information Page: NINDS)

Definitions of Holoprosencephaly:

Anterior midline brain, cranial, and facial malformations resulting from the failure of the embryonic prosencephalon to undergo segmentation and cleavage. Alobar prosencephaly is the most severe form and features anophthalmia; cyclopia; severe MENTAL RETARDATION; CLEFT LIP; CLEFT PALATE; SEIZURES; and microcephaly. Semilobar holoprosencepaly is characterized by hypotelorism, microphthalmia, coloboma, nasal malformations, and variable degrees of mental retardation. Lobar holoprosencephaly is associated with mild (or absent) facial malformations and intellectual abilities that range from mild mental retardation to normal. Holoprosencephaly is associated with CHROMOSOME ABNORMALITIES. - (Source - Diseases Database)

Holoprosencephaly is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH). This means that Holoprosencephaly, or a subtype of Holoprosencephaly, affects less than 200,000 people in the US population.
Source - National Institutes of Health (NIH)

Ophanet, a consortium of European partners, currently defines a condition rare when it affects 1 person per 2,000. They list Holoprosencephaly as a "rare disease".
Source - Orphanet


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