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What is Letterer-Siwe disease?

What is Letterer-Siwe disease?

  • Letterer-Siwe disease: A rare usually fatal condition characterized by skin lesions, bleeding tendency, enlarged liver and spleen, enlarged lymph nodes and progressive anemia. The condition is caused by excessive proliferation of histiocytes.
  • Letterer-Siwe disease: A clinical variant of Langerhans cell histiocytosis characterised by unifocal involvement of a bone (most often), skin, or lung. Patients are usually older children or adults usually presenting with a lytic bone lesion. The etiology is unknown. Morphologically, eosinophilic granuloma is characterised by the presence of Langerhans cells in a characteristic milieu which includes histiocytes, eosinophiles neutrophiles, and small, mature lymphocytes. -- 2003
    Source - Diseases Database

Letterer-Siwe disease is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH). This means that Letterer-Siwe disease, or a subtype of Letterer-Siwe disease, affects less than 200,000 people in the US population.
Source - National Institutes of Health (NIH)

Letterer-Siwe disease: Introduction

Types of Letterer-Siwe disease:

Broader types of Letterer-Siwe disease:

How serious is Letterer-Siwe disease?

Complications of Letterer-Siwe disease: see complications of Letterer-Siwe disease

What causes Letterer-Siwe disease?

Causes of Letterer-Siwe disease: see causes of Letterer-Siwe disease

What are the symptoms of Letterer-Siwe disease?

Symptoms of Letterer-Siwe disease: see symptoms of Letterer-Siwe disease

Complications of Letterer-Siwe disease: see complications of Letterer-Siwe disease

Onset of Letterer-Siwe disease: usually under 3 years of age

Can anyone else get Letterer-Siwe disease?

More information: see contagiousness of Letterer-Siwe disease
Inheritance: see inheritance of Letterer-Siwe disease

Letterer-Siwe disease: Testing

Diagnostic testing: see tests for Letterer-Siwe disease.

Misdiagnosis: see misdiagnosis and Letterer-Siwe disease.

How is it treated?

Doctors and Medical Specialists for Letterer-Siwe disease: Pediatrician ; see also doctors and medical specialists for Letterer-Siwe disease.
Treatments for Letterer-Siwe disease: see treatments for Letterer-Siwe disease
Research for Letterer-Siwe disease: see research for Letterer-Siwe disease

Name and Aliases of Letterer-Siwe disease

Main name of condition: Letterer-Siwe disease

Other names or spellings for Letterer-Siwe disease:

Abt-Letterer-Siwe syndrome, aleukemic reticulosis, aleukemic reticuloendotheliosis, LESD, L-S disease, Histiocytosis X, acute disseminated, Familial Letterer-Siwe disease

Schueller-Christian disease, Histiocytosis X, Eosinophilic granuloma, Hand-Schuller-Christian disease, Langerhans cell histiocytosis Source - Diseases Database

Familial Letterer-Siwe disease, Histiocytosis X, acute disseminated, L-S disease, LESD
Source - Office of Rare Diseases (ORD) of the National Institutes of Health (NIH)

Letterer-Siwe disease: Related Conditions

Research the causes of these diseases that are similar to, or related to, Letterer-Siwe disease:


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