Types of Mucopolysaccharidoses
Mucopolysaccharidoses: Types list
The list of types of Mucopolysaccharidoses mentioned in various sources includes:
Eight clinical types and numerous
subtypes of mucopolysaccharidoses have been identified. Although each type
differs clinically, generally, people with mucopolysaccharidoses
experience a period of normal development followed by a decline in
physical and/or mental function. Some of the more common types include:
Mucopolysaccharidosis I(MPS I), which includes Hurler,
Scheie, and Hurler/Scheie syndromes. Hurler syndrome-the
most severe form of the mucopolysaccharidoses -occurs in infancy with
symptoms such as clouding of the cornea and progressive physical and
mental disability. Death usually occurs before age 10. Patients with
Scheie syndrome experience milder symptoms and have normal intelligence,
while those with Hurler/Scheie syndrome suffer from intermediate
MPS II, also called Hunter syndrome, affects
juveniles and includes a mild and a severe form.
Signs of the severe form
are joint stiffness, mental deterioration, dwarfing, and progressive
deafness. Death usually occurs by age 15. Symptoms of the mild form
include short stature, limitation of motion, and features such as an
enlarged forehead, lips, and tongue and misaligned teeth.
Life span may be
Individuals with MPS III, or Sanfilippo syndrome,
experience progressive dementia and mental deterioration in childhood.
Death usually occurs in the late teens.
Symptoms of MPS IV, or Morquio syndrome, usually
appear in infancy and may include severe dwarfing and corneal clouding.
Intelligence is normal.
Cardiac or respiratory disease may cause death in
the third or fourth decade of life.
MPS VI, or Maroteauz-Lamy
syndrome, resembles Hurler syndrome. Onset is in infancy, however,
intelligence is normal.
Individuals may live into the second or third
Individuals with MPS VII, Sly disease, experience corneal
clouding, skeletal irregularities, and enlargement of the liver and
spleen. Intellectual impairments vary for this type of MPS.
(Source: excerpt from NINDS Mucopolysaccharidoses Information Page: NINDS)
Mucopolysaccharidoses: Related Disease Topics
More general medical disease topics related to Mucopolysaccharidoses include:
Research More About Mucopolysaccharidoses