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What is Mucopolysaccharidosis II?

What is Mucopolysaccharidosis II?

  • Mucopolysaccharidosis II: Disorder of mucopolysaccharide metabolism in juveniles.
  • Mucopolysaccharidosis II: An inborn mucopolysaccharide metabolism disorder with iduronate-2-sulfatase deficiency. Clinical characteristics are similar to those in MPS I, except for the absence of corneal clouding and slower progression of the course of disease and central nervous system deterioration. Retinal degeneration may occur, but the cornea usually remains clear. Appearance is normal at birth with excessive growth taking place during first two years of life. Two types are recognized: A severe form (MPS IIA) which is characterized mainly by mental retardation and progressive physical deterioration and early death, and a mild form (MPS IIB) in which patients may survive into adulthood. MPS IIA usually occurs between 2 and 4 years of age with progressive deterioration, chronic diarrhea, recurrent ear infections, hearing impairment, communicating hydrocephalus with increased intracranial pressure, and death at about 10 and 15 years. Obstructive airway disease, cardiac valvular dysfunction, myocardial thickening, pulmonary hypertension, coronary disease, and myocardial infarction may be superimposed. MPS IIB is milder with preservation of intelligence. The symptoms usually include hearing impairment, carpal tunnel syndrome, joint stiffness, discrete corneal opacities, and papilledema. Death may occur in early adulthood, usually from airway obstruction or cardiac failure.
    Source - Diseases Database

Mucopolysaccharidosis II is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH). This means that Mucopolysaccharidosis II, or a subtype of Mucopolysaccharidosis II, affects less than 200,000 people in the US population.
Source - National Institutes of Health (NIH)

Ophanet, a consortium of European partners, currently defines a condition rare when it affects 1 person per 2,000. They list Mucopolysaccharidosis II as a "rare disease".
Source - Orphanet

Mucopolysaccharidosis II: Introduction

Types of Mucopolysaccharidosis II:

Types of Mucopolysaccharidosis II:

Broader types of Mucopolysaccharidosis II:

Who gets Mucopolysaccharidosis II?

Patient Profile for Mucopolysaccharidosis II: Juveniles.

How serious is Mucopolysaccharidosis II?

Prognosis of Mucopolysaccharidosis II: Usually death by age 15 for severe form; can have normal lifespan for mild form.
Complications of Mucopolysaccharidosis II: see complications of Mucopolysaccharidosis II
Prognosis of Mucopolysaccharidosis II: Life span may be normal. (Source: excerpt from NINDS Mucopolysaccharidoses Information Page: NINDS)

What causes Mucopolysaccharidosis II?

Causes of Mucopolysaccharidosis II: see causes of Mucopolysaccharidosis II

What are the symptoms of Mucopolysaccharidosis II?

Symptoms of Mucopolysaccharidosis II: see symptoms of Mucopolysaccharidosis II

Complications of Mucopolysaccharidosis II: see complications of Mucopolysaccharidosis II

Can anyone else get Mucopolysaccharidosis II?

More information: see contagiousness of Mucopolysaccharidosis II
Inheritance: see inheritance of Mucopolysaccharidosis II

How is it treated?

Doctors and Medical Specialists for Mucopolysaccharidosis II: Medical Geneticist ; see also doctors and medical specialists for Mucopolysaccharidosis II.
Treatments for Mucopolysaccharidosis II: see treatments for Mucopolysaccharidosis II
Research for Mucopolysaccharidosis II: see research for Mucopolysaccharidosis II

Name and Aliases of Mucopolysaccharidosis II

Main name of condition: Mucopolysaccharidosis II

Other names or spellings for Mucopolysaccharidosis II:

MPS II, Hunter syndrome, Iduronate sulfatase deficiency, Mucopolysaccharidosis type 2, Iduronate 2-sulfatase deficiency, MPS2, Sulfoiduronate sulfatase deficiency, SIDS deficiency

Iduronate sulphatase deficiency, Hunter's syndrome Source - Diseases Database

Mucopolysaccharidosis type II Hunter syndrome- mild form, MPS II (mild)
Source - Office of Rare Diseases (ORD) of the National Institutes of Health (NIH)

Mucopolysaccharidosis II: Related Conditions

Research the causes of these diseases that are similar to, or related to, Mucopolysaccharidosis II:


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