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Diseases » Myopathy » Wikipedia
 

Myopathy in Wikipedia

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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Myopathy". (Source - Retrieved 2006-09-07 14:12:18 from https://en.wikipedia.org/wiki/Myopathy)

Introduction

In medicine, a myopathy is a neuromuscular disease in which the muscle fibers dysfunction for any one of many reasons, resulting in muscular weakness. "Myopathy" simply means disorder ("pathy" from pathology) of muscle ("myo"). This implies that the primary defect is within the muscle, as opposed to the nerves ("neuropathies" or "neurogenic" disorders) or elsewhere (e.g., the brain etc.). Muscle cramps, stiffness, and spasm can also be associated with myopathy.

Classes

Because myopathy is such a general term, there are several classes of myopathy. (ICD-10 codes are provided where available.)

  • (G71.0) Dystrophies (or muscular dystrophies) are a subgroup of myopathies characterized by muscle degeneration and regeneration. Clinically, muscular dystrophies are typically progressive, since the muscles' ability to regenerate is eventually lost, leading to progressive weakness, often leading to use of a wheelchair, and eventually death, usually related to respiratory weakness.
  • (G71.1) Myotonia
  • (G71.2) The congenital myopathies do not show evidence for either a progressive dystrophic process (i.e., muscle death) or inflammation, but instead characteristic microscopic changes are seen in association with reduced contractile ability of the muscles. Among others, different congenital myopathies include:
  • (G71.3) Mitochondrial myopathies are due to defects in mitochondria, which provide a critical source of energy for muscle.
  • (G72.3) Familial periodic paralysis
  • (G72.4) Inflammatory myopathies are caused by problems with the immune system attacking components of the muscle, leading to signs of inflammation in the muscle.
  • (G73.6) Metabolic myopathies result from defects in biochemical metabolism that primarily affect muscle
  • (M33.0-M33.1) Dermatomyositis, (M33.2) polymyositis, inclusion body myositis, and related myopathies
  • (M61) Myositis ossificans
  • (M62.89) Rhabdomyolysis and (R82.1) myoglobinurias
  • Common muscle (R25.2) cramps and (M25.6) stiffness, and (R29.0) tetany

Treatments

Because different types of myopathies are caused by many different pathways, there is no single treatment for myopathy. Treatments range from treatment of the symptomes to very specific cause-targeting treatments. Drug therapy, physical therapy, bracing for support, surgery, and even acupuncture are current treatments for a variety of myopathies.


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