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Apparent mineralocorticoid excess syndrome

Introduction: Apparent mineralocorticoid excess syndrome

Description of Apparent mineralocorticoid excess syndrome

Apparent mineralocorticoid excess syndrome: A hereditary disease characterized by childhood onset HYPERTENSION, hypokalemic alkalosis, and low RENIN and ALDOSTERONE secretion. It results from a defect in the activity of the 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2 enzyme which results in inadequate conversion of CORTISOL to CORTISONE. The build up of unprocessed cortisol to levels that stimulate MINERALOCORTICOID RECEPTORS creates the appearance of having excessive MINERALOCORTICOIDS.
Source: Diseases Database

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Source: Diseases Database

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