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Dictionary » Cilostazol


Introduction: Cilostazol

Description of Cilostazol

Cilostazol: A quinolinone derivative, 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl) butoxy]-3,4-dihydro-2(1H)-quinolinone, cellular phosphodiesterase inhibitor, more specific for phosphodiesterase III. Cilostazol is approved by FDA for the reduction of symptoms of intermittent claudication. The mechanism of the action is not fully understood. The agent and its metabolites suppress cAMP degradation with a resultant increase in cAMP in platelets and blood vessels, leading to inhibition of platelet aggregation and vasodilation. These actions may contribute to its effect, but other drugs with those properties are not known to be useful in intermittent claudication. Cilostazol is contraindicated for patients with congestive heart failure. Concomitant use with clopidogrel must be studied. (NCI)
Source: Diseases Database

Cilostazol: Related Topics

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