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Dictionary » Colorectal carcinoma

Colorectal carcinoma

Introduction: Colorectal carcinoma

Description of Colorectal carcinoma

Colorectal carcinoma: Colorectal carcinoma is a disease of Western-world lifestyle. Among both males and females, it is the second most common visceral malignancy in the United States, with an expected 185,000 new cases each year. Grossly, most colorectal carcinomas are either polypoid or of the ulcerative -infiltrating type. Adenocarcinoma is the most common carcinoma in the colon and rectum. Colorectal adenocarcinoma can be divided in three grades: Grade I (low grade or well-differentiated), grade II (average grade or moderately differentiated) and grade III (poorly differentiated). The following histopathologic features have been shown to be prognostic indicators in multivariate analysis: microacinar versus macroacinar growth pattern, endocrine cells detected by chromogranin immunohistochemistry, Crohn's-like reaction and tumor budding. The standard therapy for colorectal carcinoma is surgical resection. The 5-year crude survival rate after curative resection for colorectal carcinomas ranges between 40% and 60% in most large series (Sternberg's Diagnostic Surgical Pathology, 3rd ed., 1999). --2002
Source: Diseases Database

Colorectal carcinoma: Related Topics

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