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Dictionary » Cytochrome P-450 Enzyme System
 

Cytochrome P-450 Enzyme System

Introduction: Cytochrome P-450 Enzyme System

Description of Cytochrome P-450 Enzyme System

Cytochrome P-450 Enzyme System: A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.
Source: MeSH 2007

Cytochrome P-450 Enzyme System: Related Topics

These medical condition or symptom topics may be relevant to medical information for Cytochrome P-450 Enzyme System:

Terms associated with Cytochrome P-450 Enzyme System:

Terms Similar to Cytochrome P-450 Enzyme System:

Source - MeSH 2007

More specific terms for Cytochrome P-450 Enzyme System:

Source - MeSH 2007

Broader terms for Cytochrome P-450 Enzyme System

Source - MeSH 2007

Hierarchical classifications of Cytochrome P-450 Enzyme System

The following list attempts to classify Cytochrome P-450 Enzyme System into categories where each line is subset of the next.

MeSH 2007 Hierarchy:

MeSH 2007 Hierarchy

MeSH 2007 Hierarchy

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