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Dictionary » Cytosine arabinoside

Cytosine arabinoside

Introduction: Cytosine arabinoside

Description of Cytosine arabinoside

Cytosine arabinoside: An antimetabolite analogue of cytidine with a modified sugar moiety (arabinose instead of ribose). Cytosine arabinoside is converted to the triphosphate form within the cell and then competes with cytidine for incorporation into DNA. Because the arabinose sugar sterically hinders the rotation of the molecule within DNA, DNA replication ceases, specifically during the S phase of the cell cycle. This agent also inhibits DNA polymerase, resulting in a decrease in DNA replication and repair. (NCI04)
Source: Diseases Database

Cytosine arabinoside: class of pyrimidine nucleoside analogs used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia; antimetabolite antineoplastic agents that inhibit the synthesis of DNA with actions specific for the S phase of the cell cycle; also have antiviral and immunosuppressant properties.
Source: CRISP

Cytosine arabinoside: Related Topics

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Source: Diseases Database

More specific terms for Cytosine arabinoside:

Source - CRISP

Broader terms for Cytosine arabinoside

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The term Cytosine arabinoside can be used for:

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The description of Cytosine arabinoside may also be used for the following terms:

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