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Dactinomycin

Introduction: Dactinomycin

Description of Dactinomycin

Dactinomycin: A chromopeptide antineoplastic antibiotic isolated from the bacterium Streptomyces parvulus. Dactinomycin intercalates between adjacent guanine-cytosine base pairs, blocking the transcription of DNA by RNA polymerase; it also causes single-strand DNA breaks, possibly via a free-radical intermediate or an interaction with topoisomerase II. (NCI04)
Source: Diseases Database

Dactinomycin: A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015).
Source: MeSH 2007

Dactinomycin: Related Topics

These medical condition or symptom topics may be relevant to medical information for Dactinomycin:

Drug name confusion

Because many drug names share similar spellings or sound almost identical when spoken, it is possible to mistake the name of a particular medication. Other drugs that are sometimes confused with Dactinomycin include:

Terms associated with Dactinomycin:

Terms Similar to Dactinomycin:

Source: Diseases Database

Source - MeSH 2007

Broader terms for Dactinomycin

Source - MeSH 2007

The following terms can be used for Dactinomycin

Source: CRISP

Hierarchical classifications of Dactinomycin

The following list attempts to classify Dactinomycin into categories where each line is subset of the next.

MeSH 2007 Hierarchy:

MeSH 2007 Hierarchy

MeSH 2007 Hierarchy

External links related to: Dactinomycin

Source: Diseases Database

Interesting Medical Articles:

Medical dictionaries:

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