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Interferon-Stimulated Gene Factor 3

Introduction: Interferon-Stimulated Gene Factor 3

Description of Interferon-Stimulated Gene Factor 3

Interferon-Stimulated Gene Factor 3: A multimeric complex that functions as a ligand-dependent transcription factor. ISGF3 is assembled in the CYTOPLASM and translocated to the CELL NUCLEUS in response to INTERFERON signaling. It consists of ISGF3-GAMMA and ISGF3-ALPHA, and it regulates expression of many interferon-responsive GENES.
Source: MeSH 2007

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