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Dictionary » OKT3


Introduction: OKT3

Description of OKT3

OKT3: An anti-CD3 monoclonal antibody with immunosuppressive activity. Monoclonal Antibody OKT3 binds to and blocks the function of the CD3 receptor molecule in the membrane of human T cells. In in vitro cytolytic assays, this agent blocks both the generation and function of effector T cells. Binding of monoclonal antibody OKT3 to CD3-positive T cells, results in early activation of this T cell subset, followed by cytokine release and inhibition of CD3-positive T cell functions. CD3 has been associated in vitro with the antigen recognition structure of T cells and is essential for signal transduction. (NCI04)
Source: Diseases Database

OKT3: Related Topics

These medical condition or symptom topics may be relevant to medical information for OKT3:

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Source: Diseases Database

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