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Presenilin: membrane protein associated with early onset familial Alzheimer's disease.
Presenilin: Integral membrane proteins and essential components of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PROTEIN precursors. Mutations of presenilins lead to presenile ALZHEIMER DISEASE with onset before age 65 years.
Source: MeSH 2007
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Source - CRISP
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