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Proto-Oncogene Proteins c-abl

Introduction: Proto-Oncogene Proteins c-abl

Description of Proto-Oncogene Proteins c-abl

Proto-Oncogene Proteins c-abl: Non-receptor tyrosine kinases encoded by the c-abl gene. They are distributed in both the cytoplasm and the nucleus. c-Abl plays a role in normal hematopoiesis especially of the myeloid lineage. Oncogenic transformation of c-abl arises when specific N-terminal amino acids are deleted, releasing the kinase from negative regulation.
Source: MeSH 2007

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