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Dictionary » Suramin


Introduction: Suramin

Description of Suramin

Suramin: A polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and tumor growth factor-beta (TGF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. This agent also inhibits vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-induced angiogenesis; retroviral reverse transcriptase; uncoupling of G-proteins from receptors; topoisomerases; cellular folate transport; and steroidogenesis.(NCI04)
Source: Diseases Database

Suramin: naphthalenesulfonate antitrypanosomal and antifilarial agent; also suppresses adrenocortical cells and is used in treatment of adrenocortical cancer.
Source: CRISP

Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
Source: MeSH 2007

Suramin: Related Topics

These medical condition or symptom topics may be relevant to medical information for Suramin:

Terms associated with Suramin:

Broader terms for Suramin

Source - MeSH 2007

Source - CRISP

Hierarchical classifications of Suramin

The following list attempts to classify Suramin into categories where each line is subset of the next.

MeSH 2007 Hierarchy:

MeSH 2007 Hierarchy

MeSH 2007 Hierarchy

External links related to: Suramin

Source: Diseases Database

Interesting Medical Articles:

Medical dictionaries:

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