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Dictionary » Temozolomide


Introduction: Temozolomide

Description of Temozolomide

Temozolomide: An anticancer drug that belongs to the family of drugs called alkylating agents.
Source: National Institute of Health

Temozolomide: An orally bioavailable triazene analog of dacarbazine with antineoplastic activity. As a cytotoxic alkylating agent, temozolomide is converted at physiologic pH to the short-lived active compound monomethyl triazeno imidazole carboxamide (MTIC); MTIC's cytotoxicity is due primarily to methylation of DNA at the O6 and N7 positions of guanine, which inhibits DNA replication. Unlike dacarbazine, which is metabolized to MITC only in the liver, temozolomide is metabolized to MITC at all sites. Temozolomide penetrates well into the central nervous system. (NCI04)
Source: Diseases Database

Temozolomide: dacarbazine derivative; alkylating antineoplastic agent.
Source: CRISP

Temozolomide: Related Topics

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Broader terms for Temozolomide

Source - CRISP

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Source: CRISP

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Source: CRISP

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Source: Diseases Database

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