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Topotecan

Introduction: Topotecan

Description of Topotecan

Topotecan: A semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Topotecan inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death. Because ongoing DNA synthesis is necessary for topotecan to exert its cytotoxic effects, it is classified as an S-phase-specific agent. (NCI04)
Source: Diseases Database

Topotecan: antineoplastic drug which acts as a DNA topoisomerase inhibitor.
Source: CRISP

Topotecan: An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA TOPOISOMERASES, TYPE I.
Source: MeSH 2007

Topotecan: Related Topics

These medical condition or symptom topics may be relevant to medical information for Topotecan:

Terms associated with Topotecan:

Broader terms for Topotecan

Source - CRISP

The term Topotecan can be used for:

Source: CRISP

Other terms that may be related to Topotecan:

Source: CRISP

External links related to: Topotecan

Source: Diseases Database

Interesting Medical Articles:

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