Assessment
Questionnaire

Have a symptom?
See what questions
a doctor would ask.
 
Diseases » Neuroblastoma » Wikipedia
 

Neuroblastoma in Wikipedia

Note:Wikipedia is a user-contributed encyclopedia and may not have been reviewed by professional editors (See full Wikipedia disclaimer)

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Neuroblastoma". (Source - Retrieved 2006-09-07 13:59:07 from https://en.wikipedia.org/wiki/Neuroblastoma)

Introduction

Neuroblastoma is the most common extracranial solid cancer in infancy and childhood. It is a neuroendocrine tumor, arising from any neural crest element of the sympathetic nervous system.

Differentiation

Other tumors also have similar origins and show a wide pattern of differentiation ranging from benign ganglioneuroma to partially differentiated ganglioneuroblastoma to highly malignant neuroblastoma.

Neuroblastoma is one of the rare human malignancies known to demonstrate spontaneous regression from an undifferentiated state to a completely benign cellular appearance.

Antibody to neuron specific enolase can differentiate neuroblastoma from lymphoma, Ewing's sarcoma, and rhabdomyosarcoma. Also rosette patterns in a highly cellular tumor, is an additional characteristic of neuroblastoma. Moreover, neuroblastoma is the only solid tumor which rarely metastasizes in the lungs.

Treatment

When the lesion is localized, it is generally curable. However, long-term survival for children with advanced disease is poor despite aggressive multimodality therapy.

Recent biologic and genetic characteristics have been identified, which, when added to classic clinical staging, has allowed accurate patient assignment to risk groups so that treatment strategies can be more effectively undertaken.

After it is declared that the disease is gone, it often comes back.

References

  • Current aspects of biology, risk assessment, and treatment of neuroblastoma. Haase GM, Perez C, Atkinson JB. Semin Surg Oncol. 1999 Mar;16(2):91-104. PMID 9988866
 

By using this site you agree to our Terms of Use. Information provided on this site is for informational purposes only; it is not intended as a substitute for advice from your own medical team. The information on this site is not to be used for diagnosing or treating any health concerns you may have - please contact your physician or health care professional for all your medical needs. Please see our Terms of Use.

Home | Symptoms | Diseases | Diagnosis | Videos | Tools | Forum | About Us | Terms of Use | Privacy Policy | Site Map | Advertise