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Diseases » Neuroblastoma » Wikipedia

Neuroblastoma in Wikipedia

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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Neuroblastoma". (Source - Retrieved 2006-09-07 13:59:07 from


Neuroblastoma is the most common extracranial solid cancer in infancy and childhood. It is a neuroendocrine tumor, arising from any neural crest element of the sympathetic nervous system.


Other tumors also have similar origins and show a wide pattern of differentiation ranging from benign ganglioneuroma to partially differentiated ganglioneuroblastoma to highly malignant neuroblastoma.

Neuroblastoma is one of the rare human malignancies known to demonstrate spontaneous regression from an undifferentiated state to a completely benign cellular appearance.

Antibody to neuron specific enolase can differentiate neuroblastoma from lymphoma, Ewing's sarcoma, and rhabdomyosarcoma. Also rosette patterns in a highly cellular tumor, is an additional characteristic of neuroblastoma. Moreover, neuroblastoma is the only solid tumor which rarely metastasizes in the lungs.


When the lesion is localized, it is generally curable. However, long-term survival for children with advanced disease is poor despite aggressive multimodality therapy.

Recent biologic and genetic characteristics have been identified, which, when added to classic clinical staging, has allowed accurate patient assignment to risk groups so that treatment strategies can be more effectively undertaken.

After it is declared that the disease is gone, it often comes back.


  • Current aspects of biology, risk assessment, and treatment of neuroblastoma. Haase GM, Perez C, Atkinson JB. Semin Surg Oncol. 1999 Mar;16(2):91-104. PMID 9988866

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