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Diseases » Neurofibromatosis-2 » Inheritance

Inheritance and Genetics of Neurofibromatosis-2

Genetics of Neurofibromatosis-2:

Neurofibromatosis-2 is a genetic disease with an autosomal dominance pattern of inheritance. Sporadic mutations in the NF2 gene also occur.

Neurofibromatosis-2: Genetics Information

Genetics of Neurofibromatosis-2: The NF2 gene has been mapped to chromosome 22 and is thought to be a so-called 'tumor- suppressor gene'. Like other tumor suppressor genes (such as p53 and Rb), the normal function of NF2 is to act as a brake on cell growth and division, ensuring that cells do not divide uncontrollably, as they do in tumors. A mutation in NF2 impairs its function, and accounts for the clinical symptoms observed in neurofibromatosis sufferers. NF-2 is an autosomal dominant genetic trait, meaning it affects both genders equally and that each child of an affected parent has a 50% chance of inheriting the gene. (Source: Genes and Disease by the National Center for Biotechnology)

About inheritance and genetics:

Inheritance of Neurofibromatosis-2 refers to whether the condition is inherited from your parents or "runs" in families. The level of inheritance of a condition depends on how important genetics are to the disease. Strongly genetic diseases are usually inherited, partially genetic diseases are sometimes inherited, and non-genetic diseases are not inherited. For general information, see Introduction to Genetics.


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